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APh161 - Lecture 11: The Cytoskeleton is Always Under Construction Rob Phillips California Institute of Technology Mullins et al.

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Presentation on theme: "APh161 - Lecture 11: The Cytoskeleton is Always Under Construction Rob Phillips California Institute of Technology Mullins et al."— Presentation transcript:

1 APh161 - Lecture 11: The Cytoskeleton is Always Under Construction Rob Phillips California Institute of Technology Mullins et al.

2 The Hierarchy of Time Scales

3 Time Dependence of Gene Expression Elowitz et al. Collins et al.

4 Rate Equations and Genetic Circuits

5 The Rate Equation World View Vilar and Leibler ‘03 Wong, Gladney, and Keasling ‘03

6 Putting the Stopwatch on Cell Motility http://cmgm.stanford.edu/theriot/movies.htmhttp://cmgm.stanford.edu/theriot/movies.htm - the place to be! Courtesy of Julie Theriot et al., Stanford

7 The Eukaryotic Cell Cycle Adapted from Pollard and Earnshaw

8 Cytoskeletal Action During Cell Division

9 Cytoskeleton Mediated Mitosis Show the movies in the Lecture 11 directory – see http://www.bio.unc.edu/faculty/salmon/lab/mitosis/mitosismovies.html

10 Cell Division in Bacteria Petra Levin FtsZ rings during division

11 Polymerization Processes 1: Tobacco Mosaic Virus Caspar

12 Dynamics of Molecular Motors Science, Vol 300, Issue 5628, 2061-2065, 27 June 2003 - Yildiz et al.

13 Rate Equations: Decay Processes

14 Rate Equations: Sum Over Trajectories

15 Rate Equations: Birthing Reactions

16 A reminder on the cytoskeleton

17 Actin, Microtubules, Intermediate Filaments

18 Actin Polymerization Rate in vitro

19 ParM Length Distribution Mullins et al., Science 2004

20 Actin and its Partners

21 Microtubule Dynamics: Part of the Polymerization Puzzle

22 Microtubule Dynamics In Vitro Show Borisy movies, http://www.borisylab.nwu.edu/pages/supplemental/treadmill.html

23 Life at the Leading Edge

24 The Story of ParM (Dyche Mullins et al.)


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