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1 Kumar et al. CCM. 2006:34:1589-96. Cumulative Initiation of Effective Antimicrobial Therapy and Survival in Septic Shock time from hypotension onset.

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Presentation on theme: "1 Kumar et al. CCM. 2006:34:1589-96. Cumulative Initiation of Effective Antimicrobial Therapy and Survival in Septic Shock time from hypotension onset."— Presentation transcript:

1 1 Kumar et al. CCM. 2006:34:1589-96. Cumulative Initiation of Effective Antimicrobial Therapy and Survival in Septic Shock time from hypotension onset (hrs) 0-0.50.5-1 1-22-33-44-55-66-9 9-12 12-2424-36 36+ fraction of total patients 0.0 0.2 0.4 0.6 0.8 1.0 survival fraction cumulative antibiotic initiation

2 2 Funk and Kumar, Critical Care Clinics 2011 (in press)

3 3 Kumar et al, CCM. 2006:34:1589-96. Mortality Risk with Increasing Delays in Initiation of Effective Antimicrobial Therapy Time (hrs) 1-1.992-2.993-3.994-4.995-5.996-8.99 9-11.99 12-23.9924-35.99 > 36 Odds Ratio of Death (95% Confidence Interval) 1 10 100

4 4 Risk of Death with Increasing Antimicrobial Delays: Subgroups Kumar et al, CCM. 2006:34:1589-96. Adjusted Odds Ratio of Death 1.01.11.21.3 all documented suspected culture + culture - bacteremia + bacteremia - community nosocomial gram + gram - fungal respiratory urinary tract intra-abdominal skin/soft tissue 1385 769 608 1546 459 1695 2154 N 912 1242 768 584 838 131 230 156 641 Survival = 0.79/1.119 x x = delay (hrs)

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