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Review of muscle cell structure and phenotype plasticity.

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Presentation on theme: "Review of muscle cell structure and phenotype plasticity."— Presentation transcript:

1 Review of muscle cell structure and phenotype plasticity.
BS277 Biology of Muscle Review of muscle cell structure and phenotype plasticity. LEARNING OBJECTIVES 1. Review the structure of skeletal muscle.

2 Review of muscle structure. Organism to cell.
6 8 10 4 5 2 6 7 1 10 3 8 7 10 11 9 15 4 18 12 16 10 17 14 8 13 6

3 Brachium Tendon Skeletal muscle / biceps Epimysium Blood vessels and nerves Perimysium Muscle fascicle Muscle fibre / myocyte/muscle cell Blood vessels Endomysium Capillary Sarcolemma Sarcoplasm Nucleus Mitochondria Nerve Satellite cell

4

5 Overview of Muscle Development.

6 Review of muscle structure. Cell to organelle.
2 1 3 2 6 4 7 1 1 4 11 10 9 5 8

7 Sarcolemma Sarcoplasm Nucleus Myofibril Sarcoplasmic reticulum Terminal cisterna Mitochondrion T-tubule Triad Thick myofilament Thin myofilament

8 Review of muscle structure.
Cell to organelle.

9 Review of muscle structure. Myofibril banding pattern.
I band A band Z line H zone Titin Thin myofilament Thick myofilament Zone of overlap M line Sarcomere

10 Review of muscle structure. Myofibril banding pattern.

11 The molecular basis of the sarcomere banding pattern
Thin myofilament Thick myofilament α-actinin Titin Titin

12 The molecular basis of myofilament structure

13 The molecular basis of myofilament structure

14 Sliding filaments and muscle contraction

15 Overview of the regulation
of muscle contraction

16 The active state. Initiation of cross bridge cycling.

17 The cross bridge cycle. Step 1.

18


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