1. Catalyzing ways of thinking

2. Ferocious Beauty: Genome Liz Lerman Dance Exchange World Premiere February 3, 2006 Wesleyan University

5. Scientist as a Choreographer is

6. Biological Processes Viewing c.f. Describing c.f. Modeling Representations? Levels of organization? Units? Rules? Choreography?

7. Algorithm

8. Choreography of Biological Processes Local rules? Global behavior?

9. Science Choreography Viewing a biological process Describing a biological process –Component identification / parts lists –Initial superficial understanding Modeling a biological process –Deep understanding –Relationships between parts –Choreography

10. Molecular biology concepts from informatics perspective Biological machine –What does this mean ? –Examples ? –What does this mean physically ? –Choreograph a biological machine

11. Molecular biology concepts from informatics perspective Algorithm in biology –What does this mean ? –Examples ? –Local rules ? –Emergent behavior –Choreograph a biological algorithm

12. Key concept in molecular biology and bioinformatics Base pairing –Why key? Choreograph base pairing –Key properties? –C.f. covalent

13. Protein Translation From Alberts et al. Molecular Biology of the Cell 2002

14. Protein Translation From Alberts et al. Molecular Biology of the Cell 2002

15. Protein Translation Initiation From Alberts et al. Molecular Biology of the Cell 2002

16. Protein Translation Initiation From Alberts et al. Molecular Biology of the Cell 2002

17. The core of molecular biology 4 X 4 X 4 X…….. 4 n DNA is a code

18. Zipping and Unzipping

19. Molecular biology concepts from informatics perspective Consensus sequence –What does this mean ? –Examples ? –What does this mean physically ? –Choreograph recognition of consensus sequence by biological machine

20. Zipping and Unzipping Central to biology DNA replication RNA transcription Central to molecular biology technologies Southern, Northern, PCR, microarrays

21. Zipping and Unzipping Microarray technology Power? Implications? Ethics? Central to biology DNA replication RNA transcription Central to molecular biology technologies Southern, Northern, PCR, microarrays