1. Stress Physiology

2. Adrenocorticotropic Hormone Corticotropin Releasing Hormone Glucocorticoid = Stress Hormone Hypothalamic-Pituitary-Adrenal AXIS

3. Catecholamines = Epinephrine, Norepinephrine

4. Adrenocorticotropic Hormone Corticotropin Releasing Hormone Glucocortoid Increase Energy Available Reduce Inflammation Reduce Histamines Reduce immunity

5. STRESS Sympathetic ANS Increase Serum Glucose Liver Glycogen Glucose Increase plasma fatty acids available for energy Endorphin ReleaseDecreased PAIN

6. Acute Stress(ors) Short-Term; quick decisive action required for survival

7. Acute Stress Response Increase Energy Available Endorphin Release Decreased PAIN FLIGHT or FIGHT (seconds) Glucocorticoid Response = Minutes-Hours

8. Chronic Stress(ors) = long term, persistent Physical, Emotional, Sexual AbuseDemanding Job Poverty, MalnourishmentDepression, Anxiety

9. Chronic Stress Response General Adaptation Syndrome (Seyle) Body’s Initial Response (Cortisol, Epi/Norepi, Endophins) Increase Energy Available, Increase CO, MAP Suppress Immune System, Reduce Pain CHRONIC STRESSOR

10. Chronic Stress Response General Adaptation Syndrome (Seyle) Body’s Initial Response (Cortisol, Epi/Norepi, Endophins) Increase Energy Available, Increase CO, MAP Suppress Immune System, Reduce Pain Continuation of Body is moving to a new ‘setpoint’ that is OPTIMAL for stressful conditions ALLOSTASIS CHRONIC STRESSOR

11. Chronic Stress Response General Adaptation Syndrome (Seyle) Body’s Initial Response (Cortisol, Epi/Norepi, Endophins) Increase Energy Available, Increase CO, MAP Suppress Immune System, Reduce Pain Continuation of Body is moving to a new ‘setpoint’ that is OPTIMAL for stressful conditions ALLOSTASIS Exhaustion Energy Stores depleted Myocardium fatigued Blood vessels damaged Infection prevalent Wounds don’t heal CHRONIC STRESSOR

12. What to DO about Chronic Stress? “What fits your busy schedule better, exercising One hour a day or being dead 24 hours a day?” 1)Remove the STRESSOR! 2) EFFECTIVELY Cope with the STRESSOR!