1. NSF DAYS at Binghamton University Directorate for Biological Sciences National Science Foundation Diane M. Witt, PhD. www.NSF.gov

2. National Science Foundation Director Deputy Director Directorates Biological Sciences Computer & Information Science & Engineering Education & Human Resources Engineering Geosciences Mathematical & Physical Sciences Social, Behaviorial & Economic Sciences Offices Budget, Finance & Award Management Information & Resource Management Office of the Director Legislative & Public Affairs Equal Opportunity Programs General Counsel Integrative Activities Polar Programs National Science Board Office of Inspector General

4. Biological Sciences Directorate Mission To enable the discoveries for understanding life Vision Inspiring research and education at the frontiers of the life sciences

5. Directorate for Biological Sciences Research Resources Research Resources Human Resources Division of Biological Infrastructure (DBI) Division of Biological Infrastructure (DBI) Behavioral Systems Developmental Systems Developmental Systems Neural Systems Physiological & Structural Systems Physiological & Structural Systems Integrative Organismal Systems (IOS) Integrative Organismal Systems (IOS) Divisions Clusters Molecular & Cellular Biosciences (MCB ) Molecular & Cellular Biosciences (MCB ) Biomolecular Systems Biomolecular Systems Cellular Systems Genes & Genome Systems Genes & Genome Systems Population & Evolutionary Processes Division of Environmental Biology (DEB) Division of Environmental Biology (DEB) Ecological Biology Ecosystem Science Ecosystem Science Systematic Biology & Biodiversity Inventories Emerging Frontiers (EF) Division

6. Division of Biological Infrastructure (DBI) Supports varied activities that provide the infrastructure for contemporary research in biology Research Resources  Databases  Curatorial improvement, computerization of research collections  Living stock collections  Major items of multi-user instrumentation  Development of new instrumentation  Research facilities at biological field stations, marine labs Human Resources  Undergraduate research and mentoring in biology  Postdoctoral research fellowships in biology

7. Integrative Organismal Systems IOS Supports research focusing on an integrative understanding of organisms. Understand why organisms are structured the way they are and function the way they do. Innovative applications of systems biology approaches (i.e., combined experimentation, computation, modeling) New conceptual and theoretical insights and predictions that may be experimentally verified

8. Integrative Organismal Systems IOS Neural Systems Cluster Organization How do genetics, developmental processes, and experience/environment interact to produce structure and function? Activation Information extraction from the environment and integration within the organism to form a decision, perception, or action Modulation Robust emergent properties that underlie adaptive behavior, learning, and complex social interactions

9. Integrative Organismal Systems IOS Developmental Systems Cluster Plant, Fungal, and Microbial Developmental Mechanisms Animal Developmental Mechanisms Understanding how interacting developmental processes lead to emergent properties and complex phenotypes Evolution of Developmental Systems Discovering the developmental processes shared by all organisms and those singular ones that produce diversity

10. Integrative Organismal Systems IOS Behavioral Systems Cluster Animal Behavior Social and reproductive behavior Behavioral ecology and physiology Neural and hormonal mechanisms Development, function, and mechanisms Evolutionary history

11. Integrative Organismal Systems IOS Physiological & Structural Systems Symbiosis, Defense and Self-recognition Processes and structures that mediate intimate interactions between two or more organisms Organism – Environment Interactions Structures and processes that affect organismal performance under routine, changing, or stressful environmental conditions Processes, Structures and Integrity Structural and functional properties and interactions that orchestrate daily existence

12. Division of Environmental Biology (DEB) DEB supports fundamental research on: origins, functions, relationships, interactions, and evolutionary history of populations, species, communities, and ecosystems. Scientific emphases include systematic biology, biotic surveys & inventories, molecular genetic and genomic evolution, mesoscale ecology, conservation biology, global change, and restoration ecology.

13. Environmental Sciences (DEB)  Ecological Biology  Ecosystem Science  Population & Evolutionary Processes  Systematic Biology & Biodiversity Inventories

14. Molecular & Cellular Biosciences (MCB) Biomolecular Systems  Structure, function, dynamics, interactions, and interconversions of biological molecules  Individual macromolecules to the large-scale integration of metabolic and energetic processes  Development of cutting-edge technologies  Mechanistic studies of the regulation and catalysis of enzymes and RNA  Higher-order characterization of the biochemical processes by which all organisms acquire, transform, and utilize energy from substrates

15. Cellular Systems (MCB)  Cellular Systems Cluster focuses on the structure, function, and regulation of plant, animal and microbial cells, and their interactions with the environment and with one another.  Areas supported include studies of the structure, function, and assembly of cellular elements, such as the cytoskeleton, membranes, organelles, intracellular compartments, intranuclear structures, and extracellular matrix, including eukaryotic and prokaryotic cell walls and envelopes.

16. Genes & Genomes Systems (MCB)  Genomes and genetic mechanisms in all organisms, whether prokaryote, eukaryote, phage, or virus.  The structure, maintenance, expression, transfer, and stability of genetic information in DNA, RNA, and proteins and how those processes are regulated.  Genome organization, molecular and cellular evolution, replication, recombination, repair, and vertical and lateral transmission of heritable information.  Processes that mediate and regulate gene expression, such as chromatin structure, epigenetic phenomena, transcription, RNA processing, editing and degradation, and translation.

17. Directorate for Biological Sciences

18. BIO 2009 Priorities Life in Transition Microbial Systems Synthetic Biology Adaptive Systems Technology

19. Funding Opportunities in BIO Life in Transition (LiT)

20. Origins How, where and when did life on Earth begin? How did the biological complexity of life emerge from pre-biotic chemistry and geochemistry? Open system chemistry Self-sustaining biochemistry Basic elements DNA World RNA World H 2 + CO 2 => [ HCO ] n Self- replication

21. Energy How is energy obtained and used by living systems to sustain life? Understanding natural energy transduction systems will inspire the development of biology- based technologies capable of delivering sustainable, renewable, efficient energy. Chloropla sts Assemble the basics PS IAuAg -/+ photon e-e- e-e- e-e- e-e- Applied Photosynthes Barry Bruce (UTN), NSF/EF

22. Adaptation Transformations and Transitions in the Story of Life Understanding life’s resilience and adaptation will reduce uncertainty about the future of life on Earth in response to global climate change. Changes Diversity What will survive, and how?

23. Transdisciplinary Interdisciplinary Multi-disciplinary Disciplinary Life Sciences In Transition

24. Funding Opportunities in BIO Microbial Systems in the Biosphere (MSB) Replaces Microbial Observatories and Microbial Interactions and Processes (MO/MIP) Solicitation

25. Synthetic Biology What are the indispensable requirements for life? What are: The physical rules for cell membrane assembly? The minimum gene set required to sustain life? The fundamental requirements for genome stability? ? Membrane Encapsulation Genome Stability Are There Alternative Routes to Life? Microfluidic System RNA Evolution Brian Paegel and Gerald Joyce Scripps Research Inst.

26. Synthetic Biology

27. Animal model  The primary source of data and behavioral phenomena Mathematical model  Describes hypothetical relationships between a selected subset of observations Computational model  Explores the logical consequences of the hypothetical descriptions Physical model  Explores the behavioral consequences of a hypothetical neural property operating in the animal ’ s natural environment Adaptive Systems Technology Closing the Loop of Theory, Observation, Experimentation, and Technology D. E. Koditschek, ESE Department, University of Pennsylvania

28. Funding Opportunities in BIO Solicitations Special programs with specific guidelines, deadlines, cycles (annual, biennial), etc.

29. Selected Solicitations Assembling the Tree of Life (AToL) Constructing a universal Tree of Life for all 1.7 million named species of organisms on earth Due Date: March (new solicitation forthcoming)

30. Selected Solicitations 2010 Project (will be phased out as a separate solicitation) Determine the function of all genes in Arabidopsis thaliana by the year 2010 Due Date: Feb. 19, 2009 (09-514)

31. Selected Solicitations Research Coordination Networks in Biological Sciences (RCN) Encourage and foster interactions among scientists. Create new research directions or advance a field. Due Date: June 29, 2009 (06-567)

32. Selected Solicitations Research Coordination Networks- Undergraduate Biology Education (RCN-UBE) Similar to RCN but focuses on improving Biology Education Due Date: June 29, 2009 (06-567)

33. Selected Solicitations Research Coordination Networks- Undergraduate Biology Education (RCN-UBE) Similar to RCN but focuses on improving Biology Education Due Date: June 29, 2009 (06-567)

34. Selected Multidisciplinary Programs Ecology of Infectious Diseases (BIO, GEO, SBE, NIH) Discovery of predictive models and principles governing the transmission dynamics of disease agents. Due Date: Dec. 10, 2008 (08-601) Enhancing undergraduate education and training at the intersection of the biological and mathematical sciences. Due Date: Feb. 12, 2009 (08-510) Interdisciplinary Training for Undergraduates in Biological and Mathematical Sciences (BIO,EHR,MPS)

35. Developing Expertise and Broadening Participation Funding Opportunities in NSF/BIO

36. Research Assistantships to High School Students (RAHSS) Supplement (06-027) High School Students Developing Expertise and Broadening Participation

37. Research at Undergraduate Institutions (RUI) Same target date as core programs (announcement 00-144) Research Experience for Undergraduates (REU) Sites (June 5, 2009) and Supplements (contact PD) (07-569) Undergraduates Undergraduate Research and Mentoring in the Biological Sciences (URM) Due Date: March 3, 2009 (06-591) Alan Savitzky (asavitzk@nsf.gov) Interdisciplinary Training for Undergraduates in Biological and Mathematical Sciences (UBM) Due Date: Feb. 12, 2009 (08-510) Nancy Huntly (nhuntly@nsf.gov)

38. Graduate Students Graduate Research Fellowships (GRFP) (08-593). Due date: Nov. 7, 2008 Education and Human Resources Directorate. NSF-wide program Doctoral Dissertation Improvement Grants (DDIG) (08-564). Due date: Third Friday in November. DEB and Behavioral Cluster in IOS (ddig-deb@nsf.gov; ddig-ios@nsf.gov) Integrative Graduate Education and Research Traineeship (IGERT) (new solicitation soon). Due date: April, 2009 Education and Human Resources Directorate. NSF-wide program Developing Expertise and Broadening Participation

39. Postdoctoral Fellows Postdoctoral Research Fellowships in Biology (GRFP) (07-580). Due date: Nov. 2, 2009 Division of Biological Infrastructure Broadening Participation of Under-represented Groups in Biology Carter Kimsey (ckimsey@nsf.gov) Biological Informatics Peter McCartney (pmccartn@nsf.gov) Developing Expertise and Broadening Participation Minority Postdoctoral Research Fellowships and Supporting Activities (06-586). Due date: First Monday in November BIO and SBE BIO: Carter Kimsey (ckimsey@nsf.gov)

40. Faculty and Teachers Faculty Early Career Development Program (CAREER) (08-557). Deadline: July 21, 2009 Untenured Assistant Professors Mary Chamberlin (mchamber@nsf.gov) Research Initiation Grants to Broaden Participation in Biology (RIG BP) (09-501) Deadline: Jan. 12, 2009 New investigator, new faculty Carter Kimsey (ckimsey@nsf.gov) Research Opportunity Awards (ROA) (07-041) Supplement Research Experience for Teachers (RET) (05-524) Supplement Developing Expertise and Broadening Participation

41. Realities: Funding Realities 2009 Request

42. Call Your PROGRAM DIRECTOR

43. Summary and Advice Read the Grant Proposal Guide

44. Improve the health of the Nation by conducting and supporting research: in the cause, diagnosis, prevention, and cure of human disease. National Institutes of Health NIH ______________________

45. Mission: To promote the progress of science; to advance the national health, prosperity and welfare; to secure national defense (NSF Act 0f 1950). Vision: Advancing discovery, innovation, and education beyond the frontiers of current knowledge, and empowering future generations in science and engineering.

46. Proposal Submission NSF  Online FastLane  15 Pages  Target Dates,deadlines  Suggested Reviewers  FASTLANE NIH  Grants.gov  25 Pages  3 Deadlines  eCommons FASTLANE

47. NSF  Advisory Panels  Ad Hoc Reviews NIH  Study Sections Review System ________________________

48. NSF  All proposals discussed  High Priority  Medium Priority  Low Priority  Non-competitive NIH  “Streamlined”  Priority score  Percentile  Funding line Review System ________________________

49. Merit Review Criteria  Intellectual merit  Broader impacts Best ideas from the most capable people, determined by competitive merit review.

50. Discoveries Transformative

51. Discoveries Tra ormative

52. Questions?