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… Rejection Transplantation Biology:. Kidney rejection:

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Presentation on theme: "… Rejection Transplantation Biology:. Kidney rejection:"— Presentation transcript:

1 … Rejection Transplantation Biology:

2 Kidney rejection:

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6 Allograft rejection: specificity and memmory.

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8 Adoptive transfer of skin allograft rejection.

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11 MHC-matching: microcytotoxicity assay

12 Microcytotoxicity test.

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14 Mixed Lymphocyte Reaction.

15 Luminex Cross-matching Assay: Checks for the presence of pre-existing anti-HLA antibodies in recipient serum to assess the risk of hyperacute rejection.

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26 Organ Rejection: 1.Hyperacute (immediate) : hours Pre-existing antibodies. 2.Acute: (weeks) Cell-mediated – MHC-mismatch. 3.Chronic (months, years) minor histocompatibility antigens.

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28 Transplantation of blood: blood transfusion.

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30 Hyperacute rejection of kidney graft.

31 Allo-antibodies and chronic rejection.

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41 Black: Azathioprine + corticosteroids Blue: Cyclosporin A + corticosteroids

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49 Fraternal twins cattle

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51 “Transfusion of a goat’s blood” (1892) Jules Andler (1865-1952).

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