1. ZEENAT KHAN 2ND FACULTY OF MEDICINE CHARLES UNIVERSITY CIRCULATION CHANGES AFTER BIRTH Physiology 2014-15

2. FOETAL CIRCULATION  PLACENTA  UMBILICAL VEIN  DUCTUS VENOSUS  INFERIOR VENA CAVA  RIGHT ATRIUM  FORAMEN OVALE  LEFT ATRIUM  LEFT VENTRICLE  ASCENDING AORTA  HEAD & UPPER BODY FIG. #1

3. FOETAL CIRCULATION  SUPERIOR VENA CAVA  RIGHT ATRIUM  RIGHT VENTRICLE  PULMONARY TRUNK  DUCTUS ARTERIOSUS  DESCENDING AORTA  UMBILICAL ARTERIES  PLACENTA

4. CIRCULATION AFTER BIRTH FIG. #2 CHANGES OCCUR IN: -PULMONARY CIRCULATION (LUNGS FUNCTIONAL) -SYSTEMIC CIRCULATION (PLACENTA REMOVED) … RESULTING IN CLOSURE OF: -FORAMEN OVALE -DUCTUS ARTERIOSUS -DUCTUS VENOSUS

5. CHANGES IN PULMONARY & SYSTEMIC CIRCULATION (PULMONARY)  BLOOD FLOW  ARTERIAL PRESSURE  VASCULAR RESISTANCE (SYSTEMIC)  AORTIC PRESSURE  LEFT VENTRICULAR PRESSURE  LEFT ATRIAL PRESSURE  VASCULAR RESISTANCE

6. KEY FUNCTIONAL CHANGES AFTER BIRTH 1 2 3 4 5 1 & 2 – UMBILICAL CORD CLAMPED (CLOSURE OF UMBILICAL ARTERIES AND VEIN) 3 – FORAMEN OVALE CLOSED. 4 – DUCTUS ARTERIOSUS CLOSED. 5 – DUCTUS VENOSUS CLOSED. FIG. #3

7. CONSTRICTION OF UMBILICAL VESSELS REASON: UMBILICAL CORD CUT TO DETACH NEONATE FROM PLACENTA, AS LUNGS ARE NOW FUNCTIONAL. METHOD: ARTERIES CONSTRICT INITIALLY; REDUCES FOETAL BLOOD LOSS TO THE PLACENTA. VEIN CONSTRICTS LATER; NUTRIENT-RICH BLOOD FROM PLACENTA CAN STILL REACH INFANT AFTER BIRTH. CONVERSION OF VEIN AND DISTAL PART OF ARTERIES TO FIBROUS LIGAMENTS. PROXIMAL PARTS OF UMBILICAL ARTERIES PERSIST, SUPPLYING URINARY BLADDER.

8. CLOSURE OF OVAL FORAMEN (CONNECTS R. TO L. ATRIUM) REASON: PRESSURE DIFFERENTIALS BETWEEN LEFT AND RIGHT ATRIUM REVERSE (RIGHT: LOW//LEFT: HIGH) BLOOD PREVENTED FROM FLOWING LEFT TO RIGHT. METHOD: VALVE OF OVAL FORAMENT APPOSED WITH SEPTUM SECUNDUM, CREATING FOSSA OVALIS. *PATENT FORAMEN OVALE: (ASYMPTOMATIC) ATRIAL SEPTAL DEFECT FIG. #4

9. CLOSURE OF DUCTUS ARTERIOSUS (CONNECTS PULMONARY A. TO AORTA) REASON: INCREASE IN SYSTEMIC PRESSURE ; INCREASED PRESSURE IN LEFT SIDE OF HEART AND AORTA. DECREASE IN PULMONARY RESISTANCE; DECREASED PRESSURE IN PULMONARY ARTERIES. BLOOD PREVENTED FROM FLOWING FROM AORTA TO PULMONARY TRUNK. METHOD: SMOOTH MUSCLE CONSTRICTION (INDUCED BY INCREASED OXYGEN TENSION, RELEASE OF BRADYKININ & REDUCTION IN CIRCULATING PROSTAGLANDINS) * PATENT DUCTUS ARTERIOSUM: (SYMPTOMATIC) DECREASED OXYGEN SATURATION OF AORTIC BLOOD. FIG. #5

10. CLOSURE OF DUCTUS VENOSUS (CONNECTS UMBILICAL V. TO INFERIOR VENA CAVA) REASON: FULL LIVER FUNCTION REQUIRED; PREVENTION OF ITS BYPASS BY BLOOD. METHOD: CONTRACTION OF SPHINCTER NEAR UMBILICAL VEIN INCREASES PRESSURE IN PORTAL VEIN. CONVERSION TO FIBROUS LIGAMENT. * PORTOSYSTEMIC SHUNT: (SYMPTOMATIC) FAILURE TO CLOSE, BLOOD CONTINUES BYPASSING LIVER. FIG. #6

11. STRUCTURAL CHANGES (FOETAL: ADULT) UMBILICAL ARTERIES: DISTALLY: MEDIAL UMBILICAL LIGAMENTS PROXIMALLY: SUPERIOR VESICULAR ARTERIES UMBILICAL VEIN: LIGAMENTUM TERES HEPATIS DUCTUS VENOSUM: LIGAMENTUM VENOSUM FORAMEN OVALE: FOSSA OVALIS DUCTUS ARTERIOSUS: LIGAMENTUM ARTERIOSUM

12. FOETAL & ADULT CIRCULATION (FOETAL) SHUNTS: DUCTUS VENOSUS DUCTUS ARTERIOSUS FORAMEN OVALE OXYGENATION: VIA PLACENTA PVR: HIGH SVR: LOW HEART: CHAMBERS PUMP IN PARALLEL, RIGHT SIDE DOMINANT. (ADULT) REMNANTS; NON-FUNCTIONAL. OXYGENATION VIA LUNGS LOW PVR HIGH SVR CHAMBERS PUMP IN SERIES, LEFT SIDE DOMINANT.

13. SUMMARY Placental circulation provides foetus with oxygen and nutrients. Pulmonary and systemic changes at birth lead to alterations in circulation in the neonate, enabling the infant to adjust to extra-uterine life. Main changes include closure of the following, and eventual formation of their derivatives: UMBILICAL VEIN (Lig. Teres Hepatis) UMBILICAL ARTERIES (DISTAL: Medial Umbilical Ligaments, PROXIMAL: Superior Vesicular Arteries) FORAMEN OVALE (Fossa Ovalis) DUCTUS ARTERIOSUS (Lig. Arteriosum) DUCTUS VENOSUS (Lig. Venosum) FIG. #7

14. THANKS FOR LISTENING!

15. REFERENCES Barrett, K.E. et al, Ganong’s Review of Medical Physiology (24th Ed., McGraw-Hill, New York, 2012) Despopoulos, A. and Silbernagl, S., Color Atlas of Physiology, (6 th Ed., Thieme, Stuttgart, 2009) Hall, J.E. and Guyton, A.C., Textbook of Medical Physiology (11th Ed., W.B. Saunders Company, Missisippi, 2006) Marcdante, K.J. and Kliegman, R.M., Nelson Essentials of Pediatrics (7 th Ed., Elsevier Saunders, Philadelphia, 2015) Moore, K.L. et al, Before we are Born; Essentials of Embryology and Birth Defects (8 th Ed., Elsevier Saunders, Philadelphia, 2013) Moore, K.L. and Persaud, T.V.N., The Developing Human; Clinically Oriented Embryology (9 th Ed., Elsevier Saunders, Philadelphia, 2011) Sadler, T.W., Langman’s Medical Embryology (12 th Ed., Lippincott Williams and Wilkins, Philadelphia, 2012) Webster, S. and de Wreede, R., Embryology at a Glance (1 st Ed., John Wiley & Sons, Oxford, 2012) FIG #1: Before we are Born (p.219) FIG #2: Before we are Born (p.220) FIG #3: Embryology at a Glance (p.66) FIG #4: The Developing Human (p.331) FIG #5: Before we are Born (p.221) FIG #6: The Developing Human (p.330) FIG #7: Ganong’s Review of Medical Physiology