1. ISMRM 2010 Quantitative Imaging and MS

2. N. D. Gai and J. A. Butman, NIH T1 Error Analysis for Double Angle Technique and Comparison to Inversion Recovery b-SSFP Look- Locker Acquisition Looking at T1 error in DESPOT due to imperfect RF spoiling and B1 B1 correction not via DESPOT-HIFI DESPOT underestimates T1 when TR/T1 ratio inc. from 0.01 to 0.1

3. I. Vavasour and A.L. MacKay, University of British Columbia Changes in Multiple Sclerosis Over 6 Months As Seen With T2 Relaxation and Diffusion Histograms Measures of interest for 12 RR patients: – MWF – area under T2 dist from 0-40ms/total area – Geometric mean of T2 values – DTI FA MD/ADC Diffusion eigenvalues DTI changed over time, MWF did not -> they are measuring different aspects of the pathology We can apply these techniques to our follow up scans for MSmcDESPOT but more quantitative characterization of histograms would be better FLAIR used for both tissue and lesion segmentation

4. I. Vavasour and A.L. MacKay, University of British Columbia

5. C. Laule and A.L. MacKay, University of British Columbia Myelin water fraction reduction in multiple sclerosis normal appearing white matter: Where are all the zeroes? Anatomical distribution of MWF, is it globally homogenous or locally heterogeneous? Improved sequence with better coverage and SNR at 3T for 3D multi echo T2 13 RR.94x1.88x5mm^3

6. C. Laule and A.L. MacKay, University of British Columbia Method – FSL segmentation, manual lesion seg. on FLAIR – Erosion of WM by 2 voxels to account for partial voluming – Spearman rank correlation coefficient as a non-parametric version of Pearson We should use this Results – Mean MWF negatively correlated with EDSS (R=-.57) – Female controls higher MWF than males – Zero value MWF (sort of a basic version of DV) 10% vs 4.2% of total NAWM volume have MWF=0 for MS vs normal This percentage correlates with EDSS R= 0.58 15% vs 9% in male vs female MS patients Results similar to ROIs done at 1.5T and higher than another study at 3T

7. C. Laule and A.L. MacKay, University of British Columbia Zero value MWF is distributed throughout brain but tends to be at WM/GM interfaces