1. P08026: Modular Hemodynamic Flow Simulator Jason Brown Mechanical Engineering Amanda Clark Mechanical Engineering Matthew Hicks Electrical Engineering Jonathon Kelso Electrical Engineering Charles Marion Industrial and Systems Engineering Daniel Wisniewski Electrical Engineering

2. P08026 : Project Background Design a robust, replicable test-bed Design a robust, replicable test-bed Simulate flow associated with Circulatory System Simulate flow associated with Circulatory System Previous work done by Dr. Karl Schwarz of University of Rochester Medical Center Previous work done by Dr. Karl Schwarz of University of Rochester Medical Center

3. P08026 : Concept Summary Movable Membrane Drive Movable Membrane Drive Bladder System Bladder System Compliance Chamber Compliance Chamber Vascular Resistance Network Vascular Resistance Network Sensor Network Sensor Network LabView Interface LabView Interface

4. P08026 : System Flow Loop

5. P08026 : Design Summary Standard 1” Vinyl Tubing Standard 1” Vinyl Tubing Standard 1” NPT Threaded Fittings Standard 1” NPT Threaded Fittings Teflon Tape Used at Every Threaded Opening Teflon Tape Used at Every Threaded Opening Hose Clamps Used at Every Junction Hose Clamps Used at Every Junction

6. P08026 : Design Summary Cont. Linear Actuator Designed and Programmed for Dr. Schwarz Runs Based Off User Generated Program and Cart Controls Actuator Interface Back-End Interface Front-End User Defined Interface One Command Allows for User Control via Buttons

7. P08026 : Design Summary Cont. Sensors Pressure Omega PX-209 Flow FPR-301 Dry/Wet Box

8. P08026 LabView Interface DAQ USB Compatible MCC USB-1208 Sampling Rate – 40kS/s Analog Inputs

9. P08026 : Design Summary Cont. Drive Cylinder Heart Chamber Arm Pushes Against Membrane Arm Pushes Against Membrane Fluid Forced Out through Fitting Fluid Forced Out through Fitting One Way Valves Control Flow One Way Valves Control Flow Bag Compresses Ejecting Flow Bag Compresses Ejecting Flow

10. P08026 : Design Summary Cont. Compliance Chamber 2 Designs Vascular Restriction 1”, ¾”, ½” Tubing Used Valves Used to Direct Flow

11. P08026 : Objective & Project Evaluation Pump Water Through System with Pressures Replicating 120 over 80 mmHg Capture Initial Flow/Pressure Data Able to Pressurize Compliance Chamber 200 mmHg Separate Dry/Wet Components on Two Movable Carts Provide a System with Negligible Leaks Easy Draining Procedure Documentation Customized Program for Actuator Control

12. P08026 : Difficulties & Future Improvements Difficulties Difficulties Draining Was an Initial Issue Draining Was an Initial Issue Sealing Compliance Chamber Sealing Compliance Chamber Air Bubbles Within System Air Bubbles Within System Future Improvements Future Improvements Easily Customizable Control System for Actuator Control Easily Customizable Control System for Actuator Control Refinement of Drive System Refinement of Drive System

13. P08026 : Acknowledgements Thanks to Dr. Karl Schwarz of Strong Memorial Hospital for Donation of Drive System and Other Materials Thanks to Dr. Karl Schwarz of Strong Memorial Hospital for Donation of Drive System and Other Materials Thanks to Dr. Phillips for his Guidance Thanks to Dr. Phillips for his Guidance Thanks to Richard Wisniewski for Donation of Sphygmometer Thanks to Richard Wisniewski for Donation of Sphygmometer