1. Top 5 Program (WPI) in Japan and Evaluation of Research Accomplishments International Chemical Conference 、 Taipei, 2007 （ ICCT 2007) Yoshinori Yamamoto Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Japan

2. “Global visibility" The World Premier International Research Center (WPI) Project The program provides priority support for projects aimed at creating top world-level research centers staffed at their core with the world's most leading researchers. “Global visibility" that attracts top researchers from around the world

3. Number of WPI Centers : Period : Expenditures : Approximately 5 10 years, with possible 5-year extension for projects with outstanding results (An interim evaluation will be carried out five years after the project starts.) Between 500 million yen and 2 billion yen annually per Center

4. · The WPI Research Center for Atom·Molecule·Materials (Tohoku University) · Institute for the Physics & Mathematics of the Universe (The University of Tokyo) · Institute for Integrated Cell-Material Sciences (Kyoto University) · Osaka University Immunology Frontier Research Center (Osaka University) · International Center for Materials Nanoarchitectonics (National Institute for Materials Science, Nims) Selected WPI Projects

5. Objectives of the WPI Research Center System Integration through design and evaluation Device Development based on a fundamentally new approach Development of New, Novel Compounds and Materials Establish the Premier Research Center for Materials Establish the Premier Research Center for Materials Invent/develop New Innovative Functional Materials Invent/develop New Innovative Functional Materials TU WPI Contributions to Society Theory Computer Simulations Process Technology Processing Technique Characterization Evaluation Analysis

6. Excellency in TU Research, Past, Present and Future with WPI Past Achievements (Representative Examples) Novel development of devices for optical communication (J. Nishizawa) Development of amorphous materials (T. Masumoto) Discovery of carbon nanotubes (S. Iijima, Ph.D.’65) Invention of new structural analysis of biopolymers (K. Tanaka, B.S. ‘83) Recent Achievements Creative development and practical applications of bulk metallic glasses (A. Inoue) Current World-Prominent Researchers ( based on citation analysis of ISI, July 2007 ) A. Inoue: 1 st place in Material Science T. Takahashi: 19 th place in Physics Y. Yamamoto: 17 th place in Chemistry Material Science: Physics : Chemistry : Current World Ranking of Tohoku University (based on citation analysis of ISI, July 2007) 3 rd place 9 th place 18 th place

7. Invention of Substances & Materials Characterization Theory & Simulation Device Development System Integration Atom.Molecule (Phys, Chem) Materials Engineering Inoue, Chen, Itaya Kawasaki, Tanigaki, Nishi, Yamaguchi, Shimomura, Greer, Yavari Takahashi, Yamada, Nishi Hashizume, Itaya, Tokuyama,Tsukada, Shluger Inoue, Chen, Kawasaki, Tanigaki, Adschiri, Shimomura, Lagally, Hemker Takahashi,Yamada, Hashizume,Ikuhara, Weiss, Xue Tokuyama,Tsukada, Shluger, Wan Miyazaki, Tromp, Nakazawa, Ohmi Russell, Shimomura Ohmi, Nakazawa, Gessner Esashi, Ohmi, Gessner Ohmi, Esashi, Nakazawa, Greer How Can We Achieve the Objectives? Outline of Research Fields & Fusion Inoue, Kawasaki, Adschiri, Shimomura, Lagally, Hemker Itaya,Ikuhara, Weiss,Xue Shluger, Wan Xue, Tromp, Lagally, Hashizume Tromp, Nishi, Esashi

8. North America Europe Overseas Footholds of Tohoku University around the World Asia ・ Oceania through global cooperation Tohoku University WPI Total number about 200 (2007) WPI researcher groups encompass many regions of the world (2017) Overseas Network TohokuUniversityWPI Tohoku University US Office (California) University of California (SB) MIT Harvard University Stanford University Columbia University University of Illinois University of Wisconsin University of Iowa Argonne Natl. Lab. IBM Watson and Almaden Johns Hopkins University Penn State University University of Cambridge Royal Institute of Technology in Stockholm University of Lyon Russian Academy of Sciences University of Oxford University of Heidelberg Moscow State University ETH IBM Zurich Tohoku University China Office (Beijing) Indian Institute of Science Seoul National University Korea Advanced Institute of Science and Technology Chinese Academy of Sciences Tsinghua University University of New South Wales University of Sydney

9. Current: Equal reward, equal space, equal treatments based on traditional promotion system, with the exception of some competitive grants Drastic Departure from Traditional Japanese Equalitarianism TU WPI New System and Research Environment of WPI Evaluation/Promotion based on Performance and Future Potential Fair Merit System instead of Equalitarianism Search/Secure Gifted Young Talents and Encourage/Support “Blue-Sky” Research

10. WPI Research Center for Atom·Molecule·Materials PI; 30 people (11 from US, UK, Germany, France, and China) Researchers; 90 people (associate & assistant professors, postdoctoral fellow; “~30 % “should be from abroad) Technicians and Officers; 90 people WPI-AIMR started on October 1, 2007

11. One of the Selection Criteria for PI; Citation Analysis Citation of Y. Yamamoto (on December 4, 2007) Number of Papers found: 596, Sum of the Times Cited: 17174 Average Citations per Item: 28.82, h-index: 58 Only the first 20 years are displayed.

12. ISI (Thomson, 2006) vs. Scopus (Elsevier, 2007); Ranking of Universities, based on Times Higher Education Supplement (THES) 1 (1). Harvard 2 (2). Cambridge, Oxford, Yale..... 17 (19). The University of Tokyo ….. 25 (29). Kyoto University ….. 46 (70). Osaka University ….. 102 (108). National Taiwan University ….. 102 (168). Tohoku University Scopus covers journals written in languages other than English.

14. Most Cited 10 Papers in Tetrahedron Letters during 1996-2007 Grubbs, R. H…. RCM activities of Ru-based olefin metathesis catalysts, TL, 1999, 40, 2247, 488 Frustner, A……Ru carbene complexes…….by RCM, TL, 1999, 40, 4787, 255 Miyano, S…..Synthesis of p-tert-butylthiacalix[4]arene…., TL, 1997, 38, 3971, 251 Lygo, B……Asymmetric phase transfer catalysts derived from Cinchona alkaloids…., TL, 1997, 38, 8595, 223 Chan, D. M.T…..New N- and O-arylation with PhB(OH) 2 and Cupric Acetate, TL, 1998, 39, 2933, 207 Obika, S…….Duplexes containing nucleosides analogues…TL, 1998, 39, 5401, 204 Nishiyama, M…..N-Arylpiperidines from aryl halides and piperidine under Pd tri-t- butylphosphine catalyst, TL, 1998, 39, 617, 201 Nishiyama, M…..Pd-catalysed synthesis of triarylamines from aryl halides and diarylamines, TL, 1998, 39, 2367, 198 Kalder, S. W…..Solid-supported nucleophiles and electrophiles for the purification of non-peptide small molecules, TL, 1996, 37, 7193, 196 Welton, T…..Diels-Alder reactions in room temperature ionic liquids, TL, 1999, 40, 793, 186

15. Most Cited 10 Papers in Tetrahedron during 1996- 2007 Grubbs, R. H…. Recent advances in olefin metathesis, T, 1998, 54, 4413, 1694 Lindstrom, P…..Microwave assisted organic synthesis, T, 2001, 57, 9225, 1027 Basavaiah, D…..The Baylis-Hillman reaction….T, 1996, 52, 8001, 598 Loupy, A…..A tentative rationalization of microwave effects in organic synthesis, T, 2001, 57, 9199, 576 Stanforth, S. P. Catalytic cross-coupling reactions in biaryl synthesis, T, 1998, 54, 263, 568 Hermkenns, P. H. H…..Solid-phase organic reactions, T, 1996, 52, 4527, 501 Hanessian, S…..Conformationally constrained amino acids as versatile scaffolds….T, 1997, 53, 12789, 455 List, B……Proline-catalyzed asymmetric reactions, T, 2002, 58, 5573, 409 Chan, T.-H…..Indium mediated and catalyzed reactions in aqueous media, T, 1999, 55, 11149, 409 Kotha, S…..Recent applications of the Suzuki-Miyaura cross-coupling….., T, 2002, 58, 9633, 407

16. Elsevier Journals Downloaded Frequently USA 24.68% UK 9.59% Japan 7.14% France 5.33% Korea 5.19% China 3.78% Canada 3.41% Australia 3.34% Brazil 2.90% Germany 2.84% The Lancet1.56% Tetrahedron Letters1.55% Cell0.99% Biochemical and Biophysical Research Communications 0.97% Tetrahedron0.93% FEBS Letters0.87% Journal of Chromatography A0.67% Journal of Molecular Biology0.60% Journal of the American College of Cardiology 0.58% Brain Research0.55% Countries Data in 2006

17. From  - to  -Electrophilic Lewis Acids. Application to Selective Organic Transformations Yoshinori Yamamoto Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Japan

18.  -Electrophilic Lewis Acids  -Electrophilic Lewis Acids

19. BCl 3 MgCl 2 CuClCuCl 2 AuClAuCl 3 PtCl 2 18.934.537.425.433.135.946.9 S = Benzaldehyde LA HH

20. 21.0 46.7 2.3 2.91.6 1.8 2.9 1.0 1.5 1.1 1.9 1.11.0 1.4 H1/H3H1/H3 H2/H3H2/H3 BCl 3 MgCl 2 CuClCuCl 2 AuClAuCl 3 PtCl 2 LA 0.8 1.0 1.2 1.4 1.6 1.8 Anion BrClFOTfBF 4 SbF 6 PF 6 Pt Au Pt Au Cu Ag H2/H3H2/H3 H1/H3H1/H3

21. Allylation-RCM Strategy  -Electrophilic Lewis Acids

28. Kadota, I.; Takamura, H.; Nishii, H.; Yamamoto, Y. J. Am. Chem. Soc. 2005, 127, 9246

30. 1 H NMR Spectra (400 MHz, CDCl 3 ) of Brevetoxin B Synthetic Natural

31.  -Electrophilic Lewis Acids Asao, N.; Takahashi, K.; Lee, S.; Kasahara, T.; Yamamoto, Y. JACS, 2002, 124, 12650

37. Application of Polycyclic Aromatic Hydrocarbons (PAHs )

38. Synthesis of Chrysene

39. Synthetic Plan

40. Synthesis of Anthracene

41. Acknowledgment Computations; Associate Professor Ilya Gridnev Polycyclic Ether Natural Product Synthesis (  -Electrophilic Lewis Acids); Associate Professor I. Kadota; Dr. H. Takamura; Dr. A. Ohno; Dr. C. Kadowaki; Dr. C. Park; Dr. S. Torand; Dr. P. Chan; Ms. M. Kawada; Ms. S. Saya; Ms. N. Oguro; Ms. K. Sato, Ms. K. Matsuda; Mr. H. Ueno; Mr. H. Nishii; Mr. T. Abe; Mr. S. Kikuchi; Mr. Y. Sato Coinage Metal Catalyzed Reactions (  -Electrophilic Lewis Acids); Associate Professor N. Asao; Assistant Professor T. Jin; Dr. T. Nogami; Dr. S. Lee; Dr. S. Yudha; Dr. K. Sato; Ms. K. Takahashi; Mr. T. Kasahara; Mr. H. Aikawa; Mr. Menggenbateer; Ms. Y. Isogai \; MEXT (Ministry of Education, Science, Culture, Sports, Science and Technology)