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Bioinformatics Training Program Raymond J. Carroll Department of Statistics Faculty of Nutrition Texas A&M University http://stat.tamu.edu/~carroll
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Official Name Biostatistics, Bioinformatics and the Biological Basis of Nutrition and Cancer Hence the clever acronym: http://www.stat.tamu.edu/b3nc
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History Roughly in 1997, Steve Safe started the idea of a Center for Environmental and Rural Health He needed a Biostatistics Research Core, and Jim Calvin nominated me.
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History A major point of the CERH was to foster interdisciplinary contacts Steve and Jim said: well you do nutrition, go talk to them I met Nancy Turner at a reception to start off
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History Nancy first started telling me about her data, namely the idea of colonic crypts She drew these by hand: I wished I had saved the original pictures
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History I then started talking with Nancy, Joanne Lupton and their student, Meeyoung Hong Very cool: hierarchical functional data! With location effects!
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History Naisyin Wang and I then gave the problem of these data to our student, Jeff Morris Jeff started spending lots of time in the lab, and became very knowledgeable about the biology
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History I was at U-Penn for 2 years, and just before coming back spent a week at the Canyon Ranch in Tucson Very fancy food, nothing to do
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History I wrote the first draft of the original Bioinformatics training program grant at Canyon ranch I called a person at the NCI, and she suggested that I apply for a R25T, rather than a T32. The difference: faculty salary money!
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History We also met Ed Dougherty of EE, who wrote an early paper on cDNA arrays Robb Chapkin was a huge help in the proposal as well
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Our Goal Our goal is to train statistically oriented individuals (Biostatisticians, Statisticians, Signal Processors, etc.) To function as independent researchers in a multidisciplinary environment focusing on Nutrition and cancer.
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The Challenge Even the Program Officer at the NCI thought we would not be able to recruit trainees Because of the restriction to U.S. citizens and permanent residents
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They Were Wrong! We recruited a Danh Nguyen from statistics (2001) Aniruddha Datta from EE
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Recruits in 2002 Two statisticians: Qi Zheng Mahlet Tadesse
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Our First Pre-doc (2002) Christie Spinka
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Recruits in 2003 Ivan Ivanov Kimberley Drews Wenjiang Fu
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Recruits in 2004 Michael Swartz He has a twin brother Richard, but these are actually two of Michael (I think)
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Resubmission in 2005 We have added a rotation through the Genomics Facility Core We have a systematic plan for rotations through labs, with a final choice late in fall of year 1
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Resubmission in 2005 We received the best score in our round!! We are now funded through July 2011 I am looking forward (not!) to 2010 resubmission
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Recruits in 2005 Erchin Serepedin Lan Zhou
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Recruits in 2006 Ann Chen Sujay Datta
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Other Mentors Marina Vannucci Guoyao WuRosemary Walzem David Dahl Jerry Tsai Phil Mirkes Laurie Davidson Bani Mallick
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Future Plans
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Administrative Assistant Joyce Sutherland runs the day-to-day operations for our Program, and for the proposed new Center for Statistical Bioinformatics
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Thanks! http://stat.tamu.edu/~carroll
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