1. INTERPRET - 1 Voxel localized spectrum Metabolic image Morphological image Pixel profile Nosologic image Classification Color code Overview

2. INTERPRET - 2 When entering the software…

3. INTERPRET - 3 For raw processing: a set of default parameters is proposed Depending on the echo-time (136 or 272 ms)

4. INTERPRET - 4 During the raw processing, information is displayed for the successive steps

5. INTERPRET - 5 The morphological image and a spectrum (real for 136 ms, magn for 272ms TE) are displayed

6. INTERPRET - 6 Next step is constructing the Metabolic images from the area of each peak

7. INTERPRET - 7 Default parameters are proposed for the line fitting

8. INTERPRET - 8 Spectra from the voxels in and around the VOI are then fitted Constraints: - negative peaks for lactate and alanine - same linewidth To add: - chemical shift constraints

9. INTERPRET - 9 All metabolic images are reconstructed The clinician may visualize the different metabolic images to control the fitting process

10. INTERPRET - 10 For each voxel, the fitted spectrum can be overplot on the raw data Erroneous fitting can be corrected, voxel by voxel

11. INTERPRET - 11 Next step is constructing the Nosologic image

12. INTERPRET - 12 What next ? ◊Classification process (metabolites at 136 ms TE + water information)  In progress - by Isabel Brito ◊Improve pre-processing  HLSVD  Remove artefact from deconvolution process  Baseline correction ◊C-programming + Java interface  In progress - by Blandine Chanteloup

13. INTERPRET - 13 The metabolic images are interpolated The user has to draw an ROI in the healthy tissue on the water T2 image

14. INTERPRET - 14 From the 6 metabolic maps and the water information, a profile is calculated for each pixel

15. INTERPRET - 15 The nosologic image is computed and displayed For each pixel, the highest belonging degree is color encoded

16. INTERPRET - 16 Data may be printed, saved, or the clinician may load a new patient exam

17. INTERPRET - 17 The default morphological image may be changed…

18. INTERPRET - 18 Information is available on the different step results