1. Death by Bananas The Management of Hyperkalaemia Dr. Kiaran Flanagan, Clinical Lead Acute Medicine UHCW June 2012

2. Case 1 Patient comes into ED referred by GP for high potassium of 6.7 You see the notes in the SIFT tray What do you do?...

3. How to manage Pick up notes and PUT STICKER ON THE LIST ABCDE What are you likely to find? What urgent investigation do you need to make a treatment decision? What action would you take if –1. Normal –2. Abnormal

4. What next? History... Examination... Further tests What are you looking for?

5. What next... Senior review? Actions you should recommend... –Drugs –Monitoring –Admit/ Discharge –Further checks –Anticipated future actions –How will you make this happen?

6. Case 2 Patient on the ward ATSP – unwell, vomiting Day 2 of admission – post op R hemicolectomy What do you do?

7. ABCDE Investigations? Monitoring...

8. Patient hyperkalaemic What else do you look for? What test needs to have been done? What treatment do you need to give?

9. Recheck K at 3 hours Still high... What next? –Treatment –Advice –Monitoring

10. Recheck K at 6 hours Still high... What do you do? –Treatment –Monitoring –Ask for help Who What will you tell them and how? What for

11. Case 3 Patient – Medical ALERT to Resus Drowsy High glucose What do you do????

12. What do you do? ABCDE Urgent tests What is the diagnosis? How do you manage?

13. Case 4 Cardiac Arrest Call PEA What do you think about?

14. Hyperkalaemia in cardiac arrest What do you give?

15. Case 5 Called to ward 1, pt unwell Low BP, low glucose, high potassium What do you do? –Assessment –Further tests? –Working diagnosis –Treatment?

16. Causes of Hyperkalaemia Decreased or impaired potassium excretion – renal failure, potassium-sparing diuretics, urinary obstruction, sickle cell disease, Addison disease, and systemic lupus erythematosus (SLE) Additions of potassium into extracellular space - potassium supplements (eg, PO/IV potassium, salt substitutes), rhabdomyolysis, and hemolysis (eg, blood transfusions, burns, tumor lysis) Transmembrane shifts (ie, shifting potassium from the intracellular to extracellular space) - acidosis and medication effects (eg, acute digitalis toxicity, beta-blockers, succinylcholine) Factitious or pseudohyperkalemia - improper blood collection (eg, ischemic blood draw from venipuncture technique), laboratory error, leukocytosis, and thrombocytosis

17. Causes Ineffective elimination –Kidneys –Drugs –Endocrine Excessive release from cells –Injury –Metabolic Excessive intake –Lethal Injection Pseudo

18. ECG Changes

19. How does it affect the heart? Hyperkalemia results in: Inhibition of atrial myocardial depolarization. Slowing of heart rate. Prolonging QRS duration; complexes may become bizarre. Also known as atrial standstill. Rhythm called sinoventricular rhythm. The ECG is a poor substitute for serum potassium levels to determine the degree of abnormality

20. ECG Changes From reduction of P wave amplitude and prolongation of PR interval to absence of P waves altogether. Increase of QRS duration. Increase of QT duration. Slowing of heart rate. T waves become tall and spiked. Decreased R wave amplitude

21. ECG Changes

22. 3 Principles of Treatment Stabilise myocardium Move it into cells Increase elimination

23. Dextrose - Insulin How does it work? How long for? How do you give it? What is the dose? Other considerations...

24. Calcium Gluconate How does it work? How long for? How do you give it? What is the dose? Other considerations...

25. Sodium Bicarbonate How does it work? How long for? How do you give it? What is the dose? Other considerations...

26. Calcium Resonium Hmmm....

27. More controversial Salbutamol Furosemide

28. Protocols If K > 6 mmol –Calcium Resonium –Unless – Rising fast/ patient septic then treat as below If K > 6.5 – normal ECG –Dextrose Insulin –Calcium Resonium

29. Protocols If K > 6.5 – abnormal ECG or If K > 7 –Calcium Gluconate –Dex Insulin –Salbutamol –Sodium Bicarbonate –RRT

30. Important Bits... POTENTIAL LIFE THREATENING EMERGENCY TREAT IF INDICATED TRUST BUT VERIFY RECHECK CARDIAC MONITORING EXPERT HELP PREVENTION