1. Unit Overview – pages 472-473 Viruses, Bacteria, Protists, and Fungi Viruses and Bacteria Viruses

2. Section 18.1 Summary – pages 475-483 Can you name a virus???? Viruses: nucleic acids enclosed in a protein coat and are smaller than the smallest bacterium. Non-living What is a virus?

3. Section 18.1 Summary – pages 475-483 Most biologists consider viruses to be nonliving because they don’t exhibit all the criteria for life. They don’t carry out respiration, grow, or develop. All viruses can do is replicate—make copies of themselves—and they can’t even do that without the help of living cells. What is a virus? Host cell: a cell in which a virus replicates

4. Section 18.1 Summary – pages 475-483 Viruses, such as rabies viruses and polioviruses, were named after the diseases they cause. Other viruses were named for the organ or tissue they infect. What is a virus?

5. Section 18.1 Summary – pages 475-483 What is a virus? Today, most viruses are given a genus name ending in the word “virus” and a species name. However, sometimes scientists use code numbers to distinguish among similar viruses that infect the same host. Bacteriophage: a virus that infects a bacterium (phage for short)

6. Section 18.1 Summary – pages 475-483 Viral Structure A virus has an inner core of nucleic acid, either RNA or DNA, and an outer protein coat called a capsid. Capsid Nucleic acid Envelope

7. Section 18.1 Summary – pages 475-483 Viral nucleic acid is either DNA or RNA and contains instructions for making copies of the virus. Some viruses have only four genes, while others have hundreds. Nucleic acid Capsid Viral Structure

8. Section 18.1 Summary – pages 475-483 Attachment to a host cell Before a virus can replicate, it must enter a host cell. A virus recognizes and attaches to a host cell when one of its proteins interlocks with a molecular shape that is the receptor site on the host cell’s plasma membrane.

9. Section 18.1 Summary – pages 475-483 Attachment to a host cell A protein in the tail fibers of the bacteriophage T4 recognizes and attaches the T4 to its bacterial host cell. Capsid Nucleic acid Tail Tail fiber

10. Section 18.1 Summary – pages 475-483 Viral Replication Cycles Once attached to the plasma membrane of the host cell, the virus enters the cell and takes over its metabolism. Only then can the virus replicate. Viruses have two ways of getting into host cells.

11. Section 18.1 Summary – pages 475-483 Viral Replication Cycles The virus may inject its nucleic acid into the host cell, leaving the capsid outside the cell. The virus may let the cell engulf it in a vacuole and then burst out of the vacuole.

12. Section 18.1 Summary – pages 475-483 Lytic Cycle Once inside the host cell, a virus’s genes take over the host cell’s genetic material. The viral genes alter the host cell to make new viruses.

13. Section 18.1 Summary – pages 475-483 Lytic Cycle copies of viral genes, along with viral proteins are assembled into new viruses. Once the cell is full of new viruses, they burst from the host cell, killing it. “Bursting Balloon”

14. Section 18.1 Summary – pages 475-483 Nucleic acid Bacterial host cell Bacteriophage Bacterial DNA B. Entry The bacteriophage injects its nucleic acid into the bacterial cell. A. Attachment C. Replication D. Assembly E. Lysis and Release The host’s metabolic machinery makes viral nucleic acid and proteins. New virus particles are assembled. The host cell breaks open and releases new virus particles. Lytic Cycle

15. Section 18.1 Summary – pages 475-483 Lysogenic Cycle A lysongenic cycle begins in the same way as a lytic cycle. However, in a lysogenic cycle, the viral DNA is integrated into the host cell’s chromosome. “Sneak Attack”

16. Section 18.1 Summary – pages 475-483 Disease symptoms of proviruses Many disease-causing viruses have lysogenic cycles. Three examples of these viruses are herpes simplex I, herpes simplex II that causes genital herpes, and the hepatitis B virus that causes hepatitis B.

17. Lysogenic Cycle

18. Section 18.1 Summary – pages 475-483 Disease symptoms of proviruses Another lysogenic virus is the one that causes chicken pox.

19. Section 18.1 Summary – pages 475-483 Retroviruses RNA viruses—RNA being their only nucleic acid; i.e. retrovirus Many viruses, such as the human immunodeficiency virus (HIV) that causes the disease AIDS HIV virus

20. Section 18.1 Summary – pages 475-483 Once inside a human host, HIV infects white blood cells. Newly made viruses are released into the blood stream by exocytosis and infect other white blood cells. Normal white blood cells HIV: An infection of white blood cells

21. Section 18.1 Summary – pages 475-483 Cancer and Viruses Some viruses have been linked to certain cancers in humans and animals. These viruses disrupt the normal growth and division of cells in a host, causing abnormal growth and creating tumors.

22. Section 18.1 Summary – pages 475-483 Prions and viroids Research has discovered particles that behave somewhat like viruses and cause infectious diseases. Prions: composed of proteins but have no nucleic acid to carry genetic information.

23. Section 18.1 Summary – pages 475-483 Prions and viroids Viroids: composed of a single circular strand of RNA with no protein coat. Viroids have been shown to cause infectious diseases in several plants. The amount of viroid RNA is much less than the amount found in viruses.

24. Section 18.1 Summary – pages 475-483 Plant viruses The first virus to be identified was a plant virus, called tobacco mosaic virus, that causes disease in tobacco plants. Tobacco mosaic virus causes yellow spots on tobacco leaves, making them unmarketable.

25. Section 18.1 Summary – pages 475-483 Plant viruses Not all viral plant diseases are fatal or even harmful. Some mosaic viruses cause striking patterns of color in the flowers of plants. Rembrandt tulips