1. Male genital pathology
Pathology pictures

2. 62 year old male
SCC of the penis, spreading through the vessels of the corpora cavernosa

3. Malignant penile carcinoma

4. 59 year old male with haemochromatosis and cirrhosis
Testicular atrophy

5. Atrophic testis
Low power: tunica albuginea (long arrow); seminiferous tubules (short arrow)
High power: Leydig cells (long arrow); atrophic tubules (short arrows); thickened basement membrane; lack of spermatogenesis
Low power
High power

6. A: normal testis
B: testicular atrophy  tubules have Sertoli cells but no spermatogenesis; thickened basement membrane; apparent increase in interstitial Leydig cells

7. 30 year old man with dystrophia myotonica
Advanced testicular atrophy

8. Epididymitis and orchitis

9. 71 year old male with prostatic hyperplasia
Chronic granulomatous epididymo-orchitis
Blue arrows: cream nodules comprising lipid-laden macrophages
Black arrows: hydrocoele

10. Tuberculous epididymo-orchitis
Predominantly affecting the epididymis (arrows)

11. Tertiary syphilis
Gumma (arrows) of the testis
Multiple irregular areas of necrosis surrounded by a zone of dense fibrosis
No recognisable testicular tissue remains

12. Haemorrhagic infarction of testis due to torsion of spermatic cord

13. Testis which has recently undergone infarction
Low power: tunica albuginea (long arrow); infarcted tubule (small arrow)
High power: necrotic seminiferous tubules (long arrows); oedema separating tubules (short arrows)

14. Haemorrhagic necrosis of the testis and epididymis due to torsion of the spermatic cord

15. Testicular torsion

16. Torsion of the testicular appendix

17. Bilateral cysts of epididymis

18. 40 year old male
Seminoma of the testis
Homogeneous cream colour
Testicular tumours are usually a mixture of seminoma and teratoma components

19. Seminoma of the testis
Fairly well circumscribed, pale, fleshy, homogeneous mass

20. Embryonal carcinoma
Haemorrhagic mass

21. Choriocarcinoma
Small size; marked haemorrhage and necrosis

22. 17 year old male
Malignant teratoma of the testis
Varied macroscopic appearance from one area to another

23. High power view of seminoma component: tumour cells (arrows) have large central nuclei and clear cytoplasm; fibrous connective tissue septae infiltrated with chronic inflammatory cells (arrowheads)
Immature testicular teratoma
Low power: tunica (A); residual seminiferous tubules (B); varied picture within and between fields
High power: immature mesenchyme (A); immature cartilage (B); seminoma (C)  seminoma can form a component of a mixed germ cell tumour

24. Man aged 35 with ‘cannon ball’ secondaries in the lungs and a positive pregnancy test
Immature teratoma of the testis with a choriocarcinoma component
Haemorrhagic necrosis of choriocarcinoma component (characteristic  due to tumour cells invading blood vessels)
Homogenous white areas: seminoma

25. Teratoma of the testis
Variegated cut surface with cysts

26. Mature teratoma

27. Immature teratoma

28. 72 year old male
Hydrocoele (blue arrows) with atrophic testis (red arrows)

29. 6 year old male
Hydrocoele of the spermatic cord

30. Chronic haematocoele (blue arrows) with testicular atrophy (red arrows)

31. Man aged 58
Varicocoele (blue arrows)
Appendix of epididymis (red arrows)
Hydatid of Morgagni (black arrow) with twisted pedicle

32. 72 year old male with DM complicating haemochromatosis
Prostatic abscess
Blue arrows: pyogenic membrane (abscess contents removed)

33. 83 year old male
Nodular hyperplasia of the prostate and muscle hypertrophy and trabeculation of the bladder

34. Low power
High power
Low power: increased stroma and proliferated glands (arrows)
High power: double layer of nuclei (long arrows); regular nuclei and inconspicuous nucleoli (arrowheads)
Medium power

35. Prostatic hyperplasia
Hypertrophy of bladder muscle
Cystitis
Bilateral hydroureter and hydronephrosis
Suppurative pyelonephritis

36. BPH
Well-define nodules compress the urethra into a slit-like lumen
Histology: nodules of hyperplastic glands on both sides of the urethra

38. Carcinoma in the posterior prostate

39. Adenocarcinoma of the prostate
Low power: proliferation of closely-packed small glands; infiltrating into surrounding stroma
High power: glands are closely applied (long arrows); enlarged, hyperchromatic nuclei; nuclei are irregularly arranged in the cells (arrowheads)
Low power
High power

40. Poorly differentiated prostatic adenocarcinoma
Almost complete loss of the glandular architecture, pleomorphic nulei, prominent nucleoli

41. Advanced carcinoma of the prostate

42. Adenocarcinoma of the prostate
Lower left is posterior aspect (where carcinomatous tissue is)
Solid white tissue of cancer  unlike spongy appearance of benign peripheral zone