1. Biomechanical and Histological Evaluation of a Calcium Phosphate Cement* by ELIZABETH P. FRAKENBURG, STEVEN A. GOLDSTEIN, THOMAS W. BAUER, SCOTT A. HARRIS, and ROBERT D. POSER J Bone Joint Surg Am Volume 80(8):1112-24 August 1, 1998 ©1998 by The Journal of Bone and Joint Surgery, Inc.

2. Fig. 1 Drawing showing the location of the 3.5-millimeter-high defect that was created in the proximal part of the tibia. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

3. Fig. 2 Drawing showing the location of the two eight-millimeter-diameter cylindrical defects that were created in the medial and lateral femoral condyles. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

4. Fig. 3 Graph showing the results of the compression tests on the cylindrical femoral specimens. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

5. Fig. 4 Photomicrograph of an undecalcified section, demonstrating the interface between the cement and the bone at two weeks. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

6. Fig. 5 Higher-magnification photomicrograph, made at two weeks, demonstrating the interface between the cement and the bone. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

7. Fig. 6 Low-magnification photomicrographs showing representative sections from animals killed at two, four, eight, sixteen, thirty-two, and seventy-eight weeks. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

8. Fig. 7 Photomicrograph of a section from the tibial cortex, made at sixteen weeks, showing resorption of most of the cement and replacement with cortical bone (hematoxylin and eosin, x 25). ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

9. Fig. 8 Photomicrograph, made at thirty-two weeks, showing extensive bone apposition to the cement. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

10. Fig. 9 Photomicrograph, made at thirty-two weeks and at slightly higher magnification, showing bone with features identical to haversian systems within the cement. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

11. Figs. 10-A, 10-B, and 10-C: Photomicrographs, made at seventy-eight weeks, showing the result of the bone-replacement process. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

12. Figs. 10-A, 10-B, and 10-C: Photomicrographs, made at seventy-eight weeks, showing the result of the bone-replacement process. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

13. Figs. 10-A, 10-B, and 10-C: Photomicrographs, made at seventy-eight weeks, showing the result of the bone-replacement process. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

14. Fig. 11 Low-magnification photomicrograph, made at seventy-eight weeks, showing the relative proportion of bone and cement remaining in the centrum of the metaphysis. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

15. Fig. 12 Graph showing the results of histomorphometric analysis of the slides under light microscopy, which demonstrated the progressive replacement of the cement by normal trabecular bone in the tibia. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

16. Fig. 13 Low-power (top row) and high-power (bottom row) back-scattered scanning electron micrographs of sections made at sixteen (left), thirty-two (middle), and seventy-eight weeks (right), showing evidence of continued resorption of the cement with simult... ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.

17. Fig. 14 Graph showing the results of histomorphometric analysis of the specimens containing the cylindrical femoral defects, which demonstrated much slower replacement of cement by normal bone in the trabecular region. ELIZABETH P. FRAKENBURG et al. J Bone Joint Surg Am 1998;80:1112-24 ©1998 by The Journal of Bone and Joint Surgery, Inc.