Download presentation
Presentation is loading. Please wait.
Published byAnnice Fleming Modified over 9 years ago
1
Nuclear Envelope Lamin-A Couples Actin Dynamics with Immunological Synapse Architecture and T Cell Activation by José M. González-Granado, Carlos Silvestre-Roig, Vera Rocha-Perugini, Laia Trigueros-Motos, Danay Cibrián, Giulia Morlino, Marta Blanco-Berrocal, Fernando G. Osorio, José M. P. Freije, Carlos López-Otín, Francisco Sánchez-Madrid, and Vicente Andrés Sci. Signal. Volume 7(322):ra37-ra37 April 22, 2014 ©2014 by American Association for the Advancement of Science
2
A-type lamins are increased in abundance upon T cell activation. José M. González-Granado et al., Sci. Signal. 2014;7:ra37 ©2014 by American Association for the Advancement of Science
3
Loss of A-type lamins impairs T cell activation in vitro and in vivo. José M. González-Granado et al., Sci. Signal. 2014;7:ra37 ©2014 by American Association for the Advancement of Science
4
Lamin-A enhances the activation of human J77 cells. José M. González-Granado et al., Sci. Signal. 2014;7:ra37 ©2014 by American Association for the Advancement of Science
5
Lamin-A modulates the dynamics of human J77 cell–Raji cell interactions. José M. González-Granado et al., Sci. Signal. 2014;7:ra37 ©2014 by American Association for the Advancement of Science
6
Lamin-A is required for optimal movement of TCR-CD3 complexes within the plasma membrane and TCR-dependent signaling. José M. González-Granado et al., Sci. Signal. 2014;7:ra37 ©2014 by American Association for the Advancement of Science
7
A-type lamins promote MTOC translocation and F-actin polymerization in activated T cells. José M. González-Granado et al., Sci. Signal. 2014;7:ra37 ©2014 by American Association for the Advancement of Science
8
The lamin-A–mediated increase in the extent of T cell activation requires a physical connection between the nucleus and the cytoskeleton through the LINC complex. José M. González-Granado et al., Sci. Signal. 2014;7:ra37 ©2014 by American Association for the Advancement of Science
Similar presentations
© 2024 SlidePlayer.com Inc.
All rights reserved.