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Aclinical Utility of measuring [IFX] & HACA in Pts with IBD Afif w, et al. Am J Gastroenterol. 2010;105:1133-1139
![Aclinical Utility of measuring [IFX] & HACA in Pts with IBD Afif w, et al.](http://images.slideplayer.com/14/4478889/slides/slide_1.jpg "Am J Gastroenterol. 2010;105:")
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Results for IBD Pt with IFX Loss of Response HACA (+) Therapeutic [IFX] > 12 mcg/ml @ 4wk SubTherapeutic [IFX] < 12 mcg/ml @ 4wk ∆ Anti-TNFα ↑ IFX dose or Freq ∆ Anti-TNFα Inactive IBD Endo/Rad 62% of pts Active IBD Endo/Rad 38% Investigate alternative etiology Response rate 92% Failure, ∆ Rx different mechanism Response rate 17 % ↑ IFX dose or FreqResponse rate 86 % Response rate 33 % P R McNally, DO, FACP, FACG
![Results for IBD Pt with IFX Loss of Response HACA (+) Therapeutic [IFX] > 12 4wk SubTherapeutic [IFX] < 12 4wk ∆ Anti-TNFα ↑ IFX dose or Freq ∆ Anti-TNFα Inactive IBD Endo/Rad 62% of pts Active IBD Endo/Rad 38% Investigate alternative etiology Response rate 92% Failure, ∆ Rx different mechanism Response rate 17 % ↑ IFX dose or FreqResponse rate 86 % Response rate 33 % P R McNally, DO, FACP, FACG](http://images.slideplayer.com/14/4478889/slides/slide_2.jpg "Results for IBD Pt with IFX Loss of Response HACA (+) Therapeutic [IFX] > 12 4wk SubTherapeutic [IFX] < 12 4wk ∆ Anti-TNFα ↑ IFX dose or Freq ∆ Anti-TNFα Inactive IBD Endo/Rad 62% of pts Active IBD Endo/Rad 38% Investigate alternative etiology Response rate 92% Failure, ∆ Rx different mechanism Response rate 17 % ↑ IFX dose or FreqResponse rate 86 % Response rate 33 % P R McNally, DO, FACP, FACG")
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Algorithm for IBD Pt with IFX Loss of Response HACA (+) Therapeutic [IFX] > 12 mcg/ml @ 4wk SubTherapeutic [IFX] < 12 mcg/ml @ 4wk ∆ Anti-TNFα ↑ IFX dose or Freq ∆ Anti-TNFα Inactive IBD Endo/Rad Active IBD Endo/Rad ∆ Anti-TNFα Investigate alternative etiology Failure, ∆ Rx different mechanism P R McNally, DO, FACP, FACG
![Algorithm for IBD Pt with IFX Loss of Response HACA (+) Therapeutic [IFX] > 12 4wk SubTherapeutic [IFX] < 12 4wk ∆ Anti-TNFα ↑ IFX dose or Freq ∆ Anti-TNFα Inactive IBD Endo/Rad Active IBD Endo/Rad ∆ Anti-TNFα Investigate alternative etiology Failure, ∆ Rx different mechanism P R McNally, DO, FACP, FACG](http://images.slideplayer.com/14/4478889/slides/slide_3.jpg "Algorithm for IBD Pt with IFX Loss of Response HACA (+) Therapeutic [IFX] > 12 4wk SubTherapeutic [IFX] < 12 4wk ∆ Anti-TNFα ↑ IFX dose or Freq ∆ Anti-TNFα Inactive IBD Endo/Rad Active IBD Endo/Rad ∆ Anti-TNFα Investigate alternative etiology Failure, ∆ Rx different mechanism P R McNally, DO, FACP, FACG")
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