1. ENTRY WORK UW BIO UNIT IV: STIMULANTS UW BIOLOGY OF ADDICTION

2. DO NOW UW BIO WK 21 T 1/27 DO NOW: HOW LONG HAS NICOTINE BEEN CULTIVATED AND USED BY HUMANS? WHO WERE THE FIRST TO USE IT? KEY VOCAB ACETYLCHOLINE MUSCARINIC NICOTINIC RECEPTOR (NACHR) CYP2A6 LEARNING TARGET UNDERSTAND HOW NICOTINE IN TOBACCO WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR SUCCESS CRITERIA RELATE THE PROPERTIES OF NICOTINE (SUCH AS HALF LIFE, TOLERANCE) TO MOLECULES WITH WHICH NICOTINE INTERACTS

3. NICOTINE/TOBACCO VIDEOS A SMOKING EPIDEMIC -- THE HISTORY OF TOBACCO, AN EXCERPT ABC NEWS "DAY ONE" INVESTIGATIVE REPORT ABOUT THE INTENTIONAL MANIPULATION OF NICOTINE LEVELS IN CIGARETTES BY TOBACCO COMPANIES TO ENSURE ADDICTION. ABC NEWS "DAY ONE" INVESTIGATIVE REPORT ABOUT THE INTENTIONAL MANIPULATION OF NICOTINE LEVELS IN CIGARETTES BY TOBACCO COMPANIES TO ENSURE ADDICTION.

4. DO NOW UW BIO WK 21 TH 1/29 DO NOW: WHAT ARE SOME OF THE UNETHICAL PRACTICES THE TOBACCO INDUSTRY HAS USED TO INCREASE PROFITS? KEY VOCAB ACETYLCHOLINE MUSCARINIC NICOTINIC RECEPTOR ( N AC H R) CYP2A6 LEARNING TARGET UNDERSTAND HOW NICOTINE IN TOBACCO WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR SUCCESS CRITERIA RELATE THE PROPERTIES OF NICOTINE (SUCH AS HALF LIFE, TOLERANCE) TO MOLECULES WITH WHICH NICOTINE INTERACTS

5. DO NOW UW BIO WK 21 TGIF 1/30 DO NOW: WHICH ENZYME METABOLIZES NICOTINE? WHAT DOES IT PRODUCE AS A METABOLITE? KEY VOCAB ACETYLCHOLINE MUSCARINIC NICOTINIC RECEPTOR ( N AC H R) CYP2A6 METABOLITE LEARNING TARGET UNDERSTAND HOW NICOTINE IN TOBACCO WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR SUCCESS CRITERIA RELATE THE PROPERTIES OF NICOTINE (SUCH AS HALF LIFE, TOLERANCE) TO MOLECULES WITH WHICH NICOTINE INTERACTS

6. DO NOW UW BIO WK 21 TGIF 1/30 DO NOW: WHICH ENZYME METABOLIZES NICOTINE? WHAT DOES IT PRODUCE AS A METABOLITE? KEY VOCAB ACETYLCHOLINE MUSCARINIC NICOTINIC RECEPTOR ( N AC H R) CYP2A6 METABOLITE LEARNING TARGET UNDERSTAND HOW NICOTINE IN TOBACCO WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR SUCCESS CRITERIA RELATE THE PROPERTIES OF NICOTINE (SUCH AS HALF LIFE, TOLERANCE) TO MOLECULES WITH WHICH NICOTINE INTERACTS

7. DO NOW UW BIO WK 22 T 2/3 DO NOW: WHICH RECEPTOR DOES CAFFEINE BIND TO? AGONIST OR ANTAGONIST KEY VOCAB ADENOSINE ANTAGONIST XANTHINE METHYL LEARNING TARGET UNDERSTAND HOW CAFFEINE WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR SUCCESS CRITERIA RELATE THE PROPERTIES OF CAFFEINE (SUCH AS HALF LIFE, TOLERANCE) TO MOLECULES WITH WHICH NICOTINE INTERACTS

8. DO NOW UW BIO WK 22 W 2/4 DO NOW: HOW DOES AN INDIVIDUAL DEVELOP A TOLERANCE FOR CAFFEINE? KEY VOCAB ADENOSINE ANTAGONIST XANTHINE METHYL LEARNING TARGET UNDERSTAND HOW CAFFEINE WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR SUCCESS CRITERIA RELATE THE PROPERTIES OF CAFFEINE (SUCH AS HALF LIFE, TOLERANCE) TO MOLECULES WITH WHICH CAFFEINE INTERACTS

9. DO NOW UW BIO WK 22 TH 2/5 DO NOW: NONE KEY VOCAB INSUFFLATION ACIDIC AND BASIC CRACK DAT – DOPAMINE TRANSPORTER ADHEDONIA LEARNING TARGET I CAN CONTRIBUTE TO 3 CLASS FORUMS SUCCESS CRITERIA I WILL RESEARCH/DISCUSS EACH TOPIC WITHIN THE TIME LIMIT I WILL HELP MY GROUP ADD TO THE “MASTER LIST” OF EACH FORUM

10. DO NOW UW BIO WK 22 TGIF 2/6 DO NOW: WHAT ARE THE DIFFERENT FORMS COCAINE COMES IN THAT ARE SUBJECT TO ABUSE? KEY VOCAB INSUFFLATION ACIDIC AND BASIC CRACK DAT – DOPAMINE TRANSPORTER ADHEDONIA LEARNING TARGET UNDERSTAND HOW COCAINE WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR; SUCCESS CRITERIA EVALUATE THE INFLUENCE THAT METHOD OF INTAKE HAS ON DRUG EXPERIENCE; UNDERSTAND THE BASIC PRINCIPLES OF ACID/BASE CHEMISTRY AND HOW THEY IMPACT THE COCAINE STORY; UNDERSTAND THE REWARD PATHWAY AND HOW THIS PARTICULAR DRUG STIMULATES IT

11. DO NOW UW BIO WK 23 TGIF 2/13 DO NOW: HOW ARE EACH OF THE FOLLOWING MOLECULES ARE WITH AMPHETAMINE USE? DOPAMINE- NOREPINEPHRINE- PHENYLETHYLAMINE- KEY VOCAB INSUFFLATION ENDOGENOUS METHYL PHENYLETHYLAMINE LEARNING TARGET EXPLAIN HOW AMPHETAMINES WORK AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR. SUCCESS CRITERIA DESCRIBE HOW THE REWARD PATHWAY IS STIMULATED BY AMPHETAMINES TO BE ABLE TO RELATE THE PROPERTIES OF AMPHETAMINES (IN PARTICULAR TOLERANCE) TO OVERDOSE POTENTIAL. TO

12. DO NOW UW BIO WK 24 M 2/23 DO NOW: WHY DO YOU THINK MDMA IS CLASSIFIED AS A STIMULANT? KEY VOCAB METHYLENEDIOXY- METHAMPHETAMINE SEROTONIN SYNDROME SYMPATHOMIMETIC RETRACT LEARNING TARGET TO UNDERSTAND HOW MDMA WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR SUCCESS CRITERIA TO UNDERSTAND WHAT MDMA IS, AND HOW IS RELATED (AND NOT) TO AMPHETAMINES TO BE ABLE TO WEIGH RISKS AND BENEFITS OF THIS DRUG IN A KNOWLEDGEABLE WAY THAT ASSISTS IN WISE DECISION MAKING. TO LEARN ABOUT CONTAMINANTS, WHEN TO EXPECT THEM, WHAT THEY CONTRIBUTE. TO LEARN ABOUT ACCOUNTABILITY IN SCIENCE PUBLICATION.

13. DO NOW UW BIO WK 24 T 2/24 DO NOW: WHERE DOES MDMA BIND? KEY VOCAB METHYLENEDIOXY- METHAMPHETAMINE SEROTONIN SYNDROME SYMPATHOMIMETIC RETRACT LEARNING TARGET TO UNDERSTAND HOW MDMA WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR SUCCESS CRITERIA TO LEARN ABOUT CONTAMINANTS, WHEN TO EXPECT THEM, WHAT THEY CONTRIBUTE. TO LEARN ABOUT ACCOUNTABILITY IN SCIENCE PUBLICATION.

14. DO NOW UW BIO WK 24 W 2/25 DO NOW: WHICH NEUROTRANSMITTER DO MOST ANTIDEPRESSANTS WORK ON? KEY VOCAB MONOAMINE OXIDIDASE, MONOAMINE OXIDASE INHIBITOR TRICYCLIC SSRI (SELECTIVE SEROTONIN RECYCLING INHIBITORS) META-ANALYSIS PLACEBO EFFECT EQUILIBRIUM DISSOCIATION CONSTANT LEARNING TARGET TO UNDERSTAND HOW ANTIDEPRESSANTS WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR SUCCESS CRITERIA FURTHER INVESTIGATE THE ROLE OF MONOAMINES AND MOOD; CONSIDER HOW AND WHY DRUGS USED TO TREAT DEPRESSION CAN LEAD TO SUICIDE.

15. DO NOW UW BIO WK 24 TH 2/26 DO NOW: WHAT INFORMATION DOES THE EQUILIBRIUM DISSOCIATION CONSTANT TELL US ABOUT A NEUROTRANSMITTER? KEY VOCAB MONOAMINE OXIDASE, MONOAMINE OXIDASE INHIBITOR TRICYCLIC SSRI (SELECTIVE SEROTONIN RECYCLING INHIBITORS) META-ANALYSIS PLACEBO EFFECT EQUILIBRIUM DISSOCIATION CONSTANT LEARNING TARGET TO UNDERSTAND HOW ANTIDEPRESSANTS WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR SUCCESS CRITERIA LEARN ABOUT EQUILIBRIUM DISSOCIATION CONSTANTS IN MEASURING ABILITY TO BIND (DRUG TO TARGET); LEARN ABOUT METASTUDIES—IN PARTICULAR, ONE ATTEMPTING TO ADDRESS ANTIDEPRESSANT EFFICACY; AND CONSIDER HOW AND WHY DRUGS USED TO TREAT DEPRESSION CAN LEAD TO SUICIDE.

16. DO NOW UW BIO WK 24 TGIF 2/27 DO NOW: WHICH RECREATIONAL STIMULANT SHOULD ANTI-DEPRESSANT USERS NOT TAKE? WHY? KEY VOCAB META-ANALYSIS PLACEBO EFFECT LEARNING TARGET TO UNDERSTAND HOW ANTIDEPRESSANTS WORKS AT THE LEVEL OF THE MOLECULE, THE NEURON, THE BRAIN, AND BEHAVIOR SUCCESS CRITERIA LEARN ABOUT METASTUDIES—IN PARTICULAR, ONE ATTEMPTING TO ADDRESS ANTIDEPRESSANT EFFICACY; AND

17. DO NOW UW BIO WK 25 M 3/2 DO NOW: DO WORMS HAVE HEARTS? KEY VOCAB PLACEBO EFFECT LEARNING TARGET I CAN PREDICT WHICH TYPE OF DRUG MY WORM WAS GIVEN SUCCESS CRITERIA OBSERVE THE EFFECTS OF DRUGS ON THE PHYSIOLOGICAL FUNCTION OF LIVING ORGANISMS PERFORM DOUBLE-BLIND EXPERIMENTS OBTAIN, REFINE AND ANALYZE QUANTITATIVE DATA INVESTIGATE BLOOD PRESSURE AND PULSE AS PERIPHERAL MEASURES OF DRUG ACTION

18. DO NOW UW BIO WK 25 T 3/3 DO NOW: WHY IS THIS CONSIDERED A DOUBLE BLIND EXPERIMENT? KEY VOCAB PLACEBO EFFECT DOUBLE BLIND EXPERIMENT LEARNING TARGET I CAN PREDICT IF MY WORM WAS GIVEN A STIMULANT, DEPRESSANT OR PLACEBO BASED ON THE CHANGE IN PULSE RATE SUCCESS CRITERIA OBSERVE THE EFFECTS OF DRUGS ON THE PHYSIOLOGICAL FUNCTION OF LIVING ORGANISMS

19. DO NOW UW BIO WK 25 TH 3/5 DO NOW: AFTER YOU’VE “OBTAINED” YOUR WORM, WHAT’S THE NEXT MAJOR STEP? DO WE PUT THE WORM “IN” THE DRUGGING CHAMBER?? KEY VOCAB PLACEBO EFFECT DOUBLE BLIND EXPERIMENT LEARNING TARGET I CAN PREDICT IF MY WORM WAS GIVEN A STIMULANT, DEPRESSANT OR PLACEBO BASED ON THE CHANGE IN PULSE RATE SUCCESS CRITERIA I CAN SUCCESSFULLY DETERMINE THE “PULSE” RATE OF THE CALIFORNIA BLACK WORM I CAN CALCULATE % PULSE CHANGE ON EACH OF MY WORMS

20. DO NOW UW BIO WK 25 TGIF 3/6 DO NOW: WHY ARE YOU ASKED TO CALCULATE % PULSE CHANGE ON EACH OF YOUR WORMS? KEY VOCAB PLACEBO EFFECT DOUBLE BLIND EXPERIMENT LEARNING TARGET I CAN PREDICT IF MY WORM WAS GIVEN A STIMULANT, DEPRESSANT OR PLACEBO BASED ON THE CHANGE IN PULSE RATE SUCCESS CRITERIA I CAN SUCCESSFULLY DETERMINE THE “PULSE” RATE OF THE CALIFORNIA BLACK WORM I CAN CALCULATE % PULSE CHANGE ON EACH OF MY WORMS I CAN INTERPRET THE RESULTS GATHERED FROM THE WHOLE CLASS.

21. DO NOW UW BIO WK 27 M 3/16 DO NOW: WHAT ARE SOME OF THE SPECIFIC TOPICS WE LEARN ABOUT EACH DRUG STUDIED KEY VOCAB NONE LEARNING TARGET I CAN RESEARCH AND CREATE AN INFORMATIONAL POSTER ON AN ASSIGNED DRUG SUCCESS CRITERIA I CAN FIND RELIABLE RESOURCES TO CITE I CAN CREATE AN EDUCATIONAL POSTER PRESENTING THE INFORMATION I’VE FOUND I CAN PRESENT THIS INFORMATION TO THE CLASS

22. DO NOW UW BIO WK 27 T 3/17 DO NOW: WHAT RESOURCES ARE AVAILABLE FOR THIS PROJECT? HOW MANY SHOULD I HAVE? KEY VOCAB PROQUEST CQ RESEARCHER LEARNING TARGET I CAN RESEARCH AND CREATE AN INFORMATIONAL POSTER ON AN ASSIGNED DRUG SUCCESS CRITERIA I CAN FIND RELIABLE RESOURCES TO CITE I CAN CREATE AN EDUCATIONAL POSTER PRESENTING THE INFORMATION I’VE FOUND I CAN PRESENT THIS INFORMATION TO THE CLASS

23. DO NOW UW BIO WK 27 W 3/18 DO NOW: WHY SHOULD YOU USE SOMETHING OTHER THAT JUST “GOOGLE” FOR THIS PROJECT? KEY VOCAB PROQUEST CQ RESEARCHER GALE VIRTUAL LIBRARY LEARNING TARGET I CAN RESEARCH AND CREATE AN INFORMATIONAL POSTER ON AN ASSIGNED DRUG SUCCESS CRITERIA I CAN FIND RELIABLE RESOURCES TO CITE I CAN CREATE AN EDUCATIONAL POSTER PRESENTING THE INFORMATION I’VE FOUND I CAN PRESENT THIS INFORMATION TO THE CLASS IN A PROFESSIONAL MANNER

24. DO NOW UW BIO WK 27 TH 3/19 DO NOW: WHERE DO OPIATES BIND? KEY VOCAB ACETYL GROUP ENDORPHIN OPIATE RECEPTOR VOLTAGE-GATED CHANNEL LIGAND-GATED CHANNELS HYPERPOLARIZATION SUBSTANCE P LEARNING TARGET I CAN RESEARCH AND CREATE AN INFORMATIONAL POSTER ON AN ASSIGNED DRUG SUCCESS CRITERIA I CAN FIND RELIABLE RESOURCES TO CITE I CAN CREATE AN EDUCATIONAL POSTER PRESENTING THE INFORMATION I’VE FOUND I CAN PRESENT THIS INFORMATION TO THE CLASS IN A PROFESSIONAL MANNER

25. DO NOW UW BIO WK 27 TGIF 3/20 DO NOW: WHAT ARE ENDOGENOUS OPIOIDS CALLED? KEY VOCAB ACETYL GROUP ENDORPHIN VOLTAGE V LIGAND-GATED CHANNELS HYPERPOLARIZATION SUBSTANCE P LEARNING TARGET I CAN RESEARCH AND CREATE AN INFORMATIONAL POSTER ON AN ASSIGNED DRUG SUCCESS CRITERIA I CAN FIND RELIABLE RESOURCES TO CITE I CAN CREATE AN EDUCATIONAL POSTER PRESENTING THE INFORMATION I’VE FOUND I CAN PRESENT THIS INFORMATION TO THE CLASS IN A PROFESSIONAL MANNER