2. Genomic Pathology: One Gene, One Disease, One Medicine Robert D. Cardiff, M.D., Ph.D. Director Center for Genomic Pathology Center for Comparative Medicine Department of Pathology and Laboratory Medicine University of California, Davis http://ctrgenpath.org Gene-Specific Breast Cancer Phenotypes rasmycneu

3. GEM PROSTATE TUMORS That Mimic Human WHICH IS HUMAN? A or B? AB Elwood-Yen PMID 14522256 SPONTANEOUS HUMAN Induced by MYC

4. Genomic Medicine 1. The human genome is sequenced The genetic code has been “broken” 2. The function of each gene will be determined by phenotyping (Phenogenomics) 3. The phenotypes will be ‘induced’ in Genetically Engineered Mice (GEM)

5. The mouse is a powerful model for human genomics  Genomics will revolutionize medicine.  Mouse mutants provide the most durable and high throughput means of understanding human genomic biology.  Mouse models represent the virtual “Koch’s Postulates” of modern biology.

6.  The genome has been sequenced.  The function of each gene needs to be elucidated by phenotyping. (Phenogenomics)  Genes are associated with diseases. Diseases require microscopic validation. (Genomic Pathology)  Gene phenotyping starts with the mouse, analyzed by Genomic Pathologists. What is Genomic Pathology?

7. Far too many devastating, costly errors in the literature!

8. The Impending Crisis  Industry, NIH and other international agencies are generating huge numbers of genetically modified mice. (20,000 -200,000 new strains)  Mouse mutant phenotypes are often inadequately characterized or misinterpreted.  Not enough existing comparative pathologists to meet this need.

9. Documenting the critical shortage The PRIME and ACVP reports The PRIME and ACVP reports –Few experimental mouse pathologists –Few experienced with multiple mouse lines. –Necropsies often done without benefit of trained pathologists. –Workers often lack appropriate qualifications.

10. The Solution:  A coordinated system to share information and access available comparative pathology resources.  A world-class faculty  Streamlined interactive training of future generations of comparative pathologists.  Proper training of all levels of “parapathologists”.  Economical Web-based training programs  Proper certification of Trainees.

11. How do I Learn about Genomic Pathology? http://ctrgenpath.net

12. “GENOMIC PATHOLOGY” Divisions of Course Work offered over the Internet  LEVEL ONE: BIOLOGY OF LABORATORY MICE –DESIGNED For graduate students, fellows and technical staff –GOAL: To train the student to more effectively and accurately perform studies using a mouse model. Emphasis on identification of gross and microscopic features of the healthy and diseased animals  LEVEL TWO: PATHOLOGY OF GENETIC ENGINEERED MICE (GEM) –DESIGNED For persons with advanced degrees and Level I graduates –GOAL: To provide training in the biology and pathology of GEM for PIs.  LEVEL THREE: ADVANCED STUDIES OF GEM –DESIGNED For certified veterinary and medical pathologists who desire advanced study on GEM –GOAL: To provide graduate information on specific pathologic changes seen in many GEM strains. To prepare the pathologist to become competent in evaluating these unique changes both gross and microscopically.

13. CGP Faculty  James M. Crawford, M.D., Ph.D. Chairman of Pathology and Editor in Chief Lab Investigation (229 PubMed publications)  Stephen W. Barthold, D.V.M.. Ph.D. Professor and Director, Member NAS (211 PubMed publications), Co-author Percy and Barthold “ Rodent Pathology ”.  Rod Bronson, D.V.M. (471 PubMed publications)  Robert D. Cardiff, M.D., Ph.D., Distinguished Professor, Former Chair of UCD Pathology, Former UCD Director of Medical Informatics AAAS Fellow (234 PubMed publications)  Murray B. Gardner, M.D., Professor Emeritus, Former Chair UCD Pathology. AAAS Fellow (245 PubMed publications)  VE Ted Valli, D.V.M., M.Sc., Ph.D. Former Chair of Pathology, Guelph, Former Dean Illinois College of Veterinary Medicine (225 PubMed publications)  Jerrold M. Ward, D.V.M., Ph.D. (566 PubMed publications)  Robert R. Maronpot, D.V.M. (273 PubMed publications)  See http://ctrgenpath.net for all CGP members http://ctrgenpath.net

14. LEVEL ONE 60+ Hours of PPT

15. http://ctrgenpath.net