1. MICROBES Grand Challenge in Comparative Endocrinology

2. GPCR Models Bioinformatics, genomics Molecular Comparative Endocrinology Molecular Comparative Endocrinology Comparative Genomes Structure-Activity Relationships Identifying and Mapping New Comparative Genomes: Novel Receptors can be identified from where they are annotated as to their sequence and their percent identity Use of gene prediction models; Phylogenetic analysis Receptors of interest can be cloned, expressed and tested for function Compare to newly sequenced genomes Identifying and Mapping New Comparative Genomes: Novel Receptors can be identified from where they are annotated as to their sequence and their percent identity Use of gene prediction models; Phylogenetic analysis Receptors of interest can be cloned, expressed and tested for function Compare to newly sequenced genomes Frontiers in Comparative Endocrinology

3. GPCR Models Bioinformatics Molecular Biology Medical & Therapeutic Development Structure-Activity Relationships MOLECULAR COMPARATIVE ENDOCRINOLOGY: Site-directed mutagenesis Pharmacological Studies Identify binding sites Determine activation, binding sites and signaling pathways Propose new ligand molecules MOLECULAR COMPARATIVE ENDOCRINOLOGY: Site-directed mutagenesis Pharmacological Studies Identify binding sites Determine activation, binding sites and signaling pathways Propose new ligand molecules Example: NOVEL RECEPTORS ARE IDENTIFIED

4. Comparative Endocinology Basic, Applied and Therapeutic/Medical Models Discovery of Novel Hormones and Signaling pathways; Discovery of New Pharmaceuticals to treat human disease; Hormonally based strategies for pest control; Development of “Endocrinomics”—high through put analysis Discovery of Novel Hormones and Signaling pathways; Discovery of New Pharmaceuticals to treat human disease; Hormonally based strategies for pest control; Development of “Endocrinomics”—high through put analysis Support New Key/alternate model organisms in evolution; Mechanisms of Evolution via genome discoveries Research Cooperative Networks Support New Key/alternate model organisms in evolution; Mechanisms of Evolution via genome discoveries Research Cooperative Networks Highlight Cutting Edge Discoveries Implementation of Grand Challenges in Comparative Endocrinology Dissemination of Information to public; scientists Comparative Endocrinology

5. North American Society for Comparative Endocrinology (NASCE) Purpose: To promote the study of hormones, hormone action in diverse animal species; to foster interdisciplinary collaborations; to promote the development of databases and other research tools for comparative endocrinology; to advocate for funding for comparative endocrinology research The NASCE will become incorporated as a nonprofit organization in the spring of 2010. A website is under development and a solicitation for charter membership will be sent out at this time. The society will include scientists from Canada, the USA and Mexico. Co-chairs of the organizing committee: Bob Denver, Univ. of Michigan, USA rdenver@umich.edurdenver@umich.edu Vance Trudeau, University of Ottawa, Canada trudeauv@uottawa.catrudeauv@uottawa.ca Meetings of the NASCE will be held once every two years in the summer, to alternate with meetings of the European Society of Comparative Endocrinologists.

6. Comparative Endocinology Neuroendocrine System Developmental, Physiology Behavior Developmental, Physiology Behavior Organismal Form, Function, Survival Organismal Form, Function, Survival Interactions with the Environment Frontiers in Comparative Endocrinology CLIMATE CHANGE Comparative Endocrinology