1. IKMG - International Kidney and Monoclonal Gammopathy Research Group 2nd International Meeting La Rochelle, France, September 3-4, 2015 http://internationalkidneymonoclonalgammopathy.org Dear Friends and Colleagues, We would like to invite you to attend the second international IKMG meeting in La Rochelle which is taking place in September 2015. The goal of the IKMG is to promote research into, and understanding of, kidney diseases resulting from monoclonal gammopathies and we are very excited about the program our organizing committee has put together. We plan to include state of the art lectures on the pathology, diagnostics and treatment of monoclonal gammopathy-related kidney diseases presented by experts from around the world. A poster and plenary session will cover the latest advances in this evolving field. This meeting will hopefully stimulate exchanges between clinicians and researchers, and open up new perspectives for diagnostic and therapeutic approaches to the treatment of these rare disorders, through a better understanding of their pathophysiological mechanisms. Call for abstracts will be announced in May. La Rochelle is a very pleasant city located on the west coast of France. The meeting will be held at the Espace Encan, close to the old port in the historical city center, with a wide choice of hotels within walking distance. The social program will be a unique opportunity to discover the best local food. We look forward to meeting you in La Rochelle, Guy Touchard, Congress President Nelson Leung, IKMG President Online Registration and Hotel Reservation: http://reservation.larochelle-evenements.fr/event/registration?eventid=73&langue=UK Contact: Tiffany Barbier, La Rochelle Evenements, Quai Louis Prunier – BP 3106 17033 La Rochelle cedex 01, France Tel : (33) 5 46 45 91 43. E-mail: www.larochelle-evenements.fr Registration fees (including lunch and dinner on Thursday September 3rd): Seniors: 325 Euros MD or PhD age less than 35 years: 175 Euros Trainees, PhD students: 75 Euros The number of participants will be limited to 250, registration will close on Wednesday August 26, 2015

2. PRELIMINARY PROGRAM Thursday, Sept. 3. Monoclonal gammopathy of renal significance - MGRS 8:00 a.m. – 9:15 a.m. Introduction: Guy Touchard and Nelson Leung - The history of monoclonal gammopathies: Robert A. Kyle (Mayo Clinic, Rochester, MN, USA) - MGRS: an evolving concept: Nelson Leung (Mayo Clinic, Rochester, MN, USA) - Classification of renal disorders in monoclonal gammopathies: Guy Touchard (University of Poitiers, France) - The kidney biopsy in MGRS: recent advances in pathology: Samih Nasr (Mayo Clinic, Rochester, MN, USA) - Coffee break 9:30 a.m. – 12:30 a.m. Proximal Tubule in Monoclonal Gammopathy: From the microscope to the Lab - Light chain (LC) tubulopathy with crystals: Vivette D’Agati (Columbia University, New-York, NY, USA) - LC proximal tubulopathy without crystals: Guillermo A. Herrera (Louisiana State University, Shreveport, LA, USA) - LC-induced interstitial nephritis: Maria M. Picken (Loyola University Medical Center, Chicago, IL, USA) - Inflammatory pathways involved in proximal tubular injury: Veichi Batuman (Tulane University, New Orleans, LA, USA) - Panel discussion 2:00 p.m. – 3:00 p.m. Update on monoclonal protein detection/measurement - New free light chain assays: Ashu Wechalekar (National Amyloidosis Centre, London, UK) - Mass spectrometry: David Murray (Mayo Clinic, Rochester, MN, USA) 3:00 p.m. – 4:15 p.m. New Renal response and emerging therapies in AL amyloidosis - Assessing renal response in AL amyloidosis: Giampaolo Merlini (University of Pavia, Italy) - Anti-SAP therapy: Julian Gillmore (National Amyloidosis Centre, London, UK) - Anti-fibril therapy: Brendan Weiss (University of Pennsylvania, Philadelphia, PA, USA) - Coffee break 4:30 p.m. – 6:00 p.m. Update on the management of myeloma cast nephropathy - Chemotherapeutic options: Efstathios Kastritis (University of Athens, Athens, Greece) - Free light chain removal: Colin Hutchison (Hawke's Bay DHB, New Zealand) - Response measurement: Heinz Ludwig (Wilhelmine Hospital, Vienna, Austria) - Group discussion 6:00 p.m. Poster viewing and wine reception, dinner to follow Friday, Sept. 4 8:30 a.m. – 10:30 a.m. Update in pathophysiology: animal models - Cast nephropathy: Paul Sanders (University of Birmingham Alabama, Birmingham, AL, USA) - LC Fanconi syndrome: mouse and cellular studies: Olivier Devuyst (University of Zurich, Switzerland) - AL amyloidosis: Guillermo A. Herrera (Louisiana State University, Shreveport, LA, USA) - Randall-type MIDD: Christophe Sirac (University of Limoges, France) - Coffee break 10:45 a.m. – 12:00 a.m. C3 glomerulopathy and monoclonal gammopathy - C3 GP and monoclonal gammopathy: the disease spectrum: Frank Bridoux (University of Poitiers, France) - The complement system in C3GP and monoclonal gammopathy: Véronique Frémeaux-Bacchi (HEGP, Paris, France) 12:00 – 12:45: Extra-renal manifestations of monoclonal gammopathy: Jean Paul Fermand (Saint Louis University Hospital, Paris, France) 2:00 p.m. – 4:00 p.m. Oral communications 4:00 p.m. Closing remarks 4:30 p.m. – 5:30 p.m. IKMG board meeting Sponsors: