1. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Research Tissue Banking Making a GIFT for the future

2. Leeds Institute of Molecular Medicine Pathology and Tumour Biology History Originally part of the Leeds Alliance site model Set up in response to proposed new laws To provide people opportunity to donate for research To provide regular supply of tissues for research Very few retrieval centres for multi tissue research donation Only 1 or 2 whole body banks

3. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Research Tissues National shortage of research material which conforms to Human Tissue Act and is also Ethically compliant Sporadic availability of some tissues Some tissues not available at all Certain areas of research suffer Animal, artificial and theoretical only either partially effective in some cases not at all Need for control tissues; TMA’s, Normal

4. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Collections Investors tissues; Biomechanics, Breast Cancer Campaign, BACO, ARC Bespoke collections; on application Small one off collections ; mainly control tissues

5. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Collections Helps ensure donors wishes are respected, “I want to help others” Makes a more effective use of donation Prevents stock piling HTA compliance; don’t want another retained organs scandal

6. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Donors Donors from outside the Leeds Trust transferred to St James’s Mortuary Trust approved Funeral Directors Return to family choice within reason We pay all costs Donors are accepted out of ours and weekends but no retrievals or transfers. The on call member of staff is available for advice via National blood Service Tissue Services.

7. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Donors Need recognised diagnosis Few contraindications HIV, CJD, Hepatitis, Prefer under 72 hrs but will take up to 4 days, Pre 24 hour sample desirable

8. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Donors All donors have a Post Mortem examination; confirms diagnosis, adds research value to tissues Post Mortems by Consultant Pathologists or supervised juniors Results available to family; via GP or other Medical Professional

9. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Retrievals Only performed in a mortuary Mainly at St James’s Hospital but can be at Leeds General Infirmary Consultant Pathologist or supervised junior Full post mortem unless limitations on consent Majority of tissues retrieved through Post Mortem incision

10. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Retrievals T incision usually made, normal incision round head behind crown Hips and knees use same incision as therapeutic retrievals Any other incisions will be as unobtrusive as possible. Only take what consented Will inform Tissue Services if new tissues to be retrieved and how for consent/family interview

11. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Incisions

12. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Tissues Bespoke or requested multi samples from certain organs/structures; Lung, Breast both male and female, Renal artery, brain, colorectal. As much tumour and/or mets as available Bones/joints; whole spine, shoulders, temporal bones including inner ear. Proposed bones/joints, hips- ball and possibly socket, knees, phalanges Control tissues; colon, mesentery, liver, spleen

13. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Any Questions ?

14. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Skull

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17. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Donors Reconstructed to post retrieval appearance Relatives can view Cremation forms completed if required Aim for no funeral delays. All wishes respected All consent limitations respected/observed

18. Leeds Institute of Molecular Medicine Pathology and Tumour Biology Confidentiality All tissues anonymised, unique ID number Non identifiable information only on secure database Identifiable information securely stored Access by senior GIFT staff only Basic data set or fully redacted information only released Mechanisms in place for family follow up if necessary

19. Leeds Institute of Molecular Medicine Pathology and Tumour Biology GIFT Bank Ethically approved researchers only Access committee MTA’s, SLA’s Yearly review and report SOP’s on web site Currently operate under Trust licenses and SLA’s

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