1. Shock Center EAB Meeting December 2008 Core F Research Development Core

2. Proposed Activities 1. Provide support for the career development of junior faculty in aging research 2. Provide support for established investigators entering the aging field with new perspectives 3. Design and conduct training programs to prepare junior investigators for careers in aging research 4. Identify and support Pilot Projects with outstanding potential to advance knowledge of the basic biology of aging 5. Organize monthly Research Development Seminars given by external speakers and designed primarily to enhance the postdoctoral training experience 6. Extend the expertise and core resources of the Buck Institute to other institutions and centers 7. Encourage the entry of promising minority students and investigators into aging research

3. Junior Faculty Asst Assoc Rsch 99 00 01 02 03 04 05 06 07 08 Melov Ellerby Kapahi Hughes Zeng Lunyak RaoGill

4. Pilot Projects: 2005 Pankaj Kapahi (RL1) Nutrition-modulated lifespan changes in Drosophila Matt Gill (R21) High-throughput screening for compounds that influence lifespan in C. elegans

5. Pilot Projects: 2006 Robert Hughes (R01) Protein interaction networks in aging human muscle Xianmin Zeng (CIRM New Investigator Award) Transcription factor Olig2 in neural differentiation of human embryonic stem cells

6. Pilot Projects: 2007 Alexander Maslov (to AECOM) A mouse model to dissect the role of somatic stem cells in aging Xianmin Zeng (CIRM New Investigator Award) IGF axis in stem cell renewal and neuronal differentiation

7. Pilot Projects: 2008 Pankaj Kapahi (RL1) HIF-1 mediates dietary restriction-dependent lifespan extension via ER stress pathway in C. elegans Ram Rao (R21 pending) Human embryonic stem cell differentiation: coping with ER stress

8. Research Development Seminars