1. الاسم : سعد بن محمد نور بن محمد ولي الرقم الجامعي : 4350167 التخصص : معيد بكلية الصيدلة قسم الأدوية Pharmacology احصاءات وجداول عن طريق برامج خاصة لأغراض التدريس والبحث العلمي

2.  Preparation of Solid Dispersions (SDs)of Ibuprofen with Different Drug-Carriers: Table(I): Formulation Design of Physical Mixtures of Ibuprofen with Different Drug Carriers F15F14F13 F12 F11 F10 F9 F8 F7 F6 F5 F4 F3 F2 F1 Composition 111111111111111Ibuprofen 531βCD 531 PEG4000 531 PEG6000 531 PVP K30 531 PVP K90

3. Table(II): Formulation Design of Ibuprofen SDs Prepared by Solvent Evaporation Method F30F29F28 F27 F26 F25 F24 F23 F22 F2 1 F20 F19 F18 F17 F16 Composition 111111111111111Ibuprofen 531βCD 531 PEG4000 531 PEG6000 531 PVP K30 531 PVP K90

4.  Determination of Maximum wave Length of Ibuprofen Absorbance: Fig(1): UV Spectrum of Ibuprofen in Absolute Alcohol

5. Table(III): UV Absorbanc of Ibuprofen at λ max 221 nm in Ethanol Concentration of Ibuprofen (ug/ml) Absorbance 4 0.2312 6 0.3322 8 0.4442 10 0.5624 12 0.6678 14 0.7561 16 0.8591 18 0.9672 20 1.0829

7.  Determination of Drug Content in Different Formulae of Ibuprofen: Table(IV): Ibuprofen Content in Different Formulae Prepared with Different Drug Carrier FormulaConcentration(ug/ml)Drug content% F1200100 F219999.5 F319899 F419798.5 F519798.5 F619999.5 F719296 F819497 F919195.5 F1019698 F1119899 F1219095 F13189 94.5 F1419798.5 F1519899

8. Fig(3a): IR Spectrum of Ibuprofen

9. Fig(3b): IR Spectrum of Ibuprofen with βCD(1:5)

10. Fig(3c): IR Spectrum of Ibuprofen with PEG4000(1:5)

11. Fig(3d): IR Spectrum of Ibuprofen with PEG6000(1:5)

12. Fig(3e): IR Spectrum of Ibuprofen with PVP K30(1:5)

13. Fig(3f): IR Spectrum of Ibuprofen with PVP K90(1:5)

14. Fig(4):XRPD Diffraction of Ibuprofen with Different Drug Carriers(A: PVP K90(1:5), B: PVP K30(1:5), C: PVP K30(1:2), D: PEG 6000(1:5), E: PEG 4000(1:5), F: Ibuprofen, G: βCD(1:5)

15. Fig(5): DSC of Ibuprofen and its Physical Mixtures with Different Carriers(A: Ibuprofen ; B: PVP K30(1:5) ; C: βCD(1:5) ; D: PEG6000(1:5) ; E: PVP K90(1:5) : F: PEG 4000(1:5) ; G: PVP K90(1:2)

17. Time( min) %Ibuprofen Released PEG 6000 Witepsol H15 Cocoa butter Novata DE75 Witepsol W35 529.36.724.522.503.82 1542.718.915.113.114.29 3061.0910.226.833.454.88 4580.6113.757.314.205.66 6082.7017.817.834.666.13 7586.4519.6210.245.226.86 9092.6421.5013.895.917.36 Table(X): Release of Ibuprofen from Different Suppository Bases: