1. Recife 2014 1-what is it ? 2-who are we ? 3-our mission, our results 4-our project Cancer Research Center of Toulouse UMR1037 Inserm - Université Toulouse III Paul Sabatier - CNRS

2. Oncopole of Toulouse: a priority of Midi Pyrénées

3. Institut Universitaire du Cancer - Oncopole of Toulouse Institut Universitaire du Cancer - Oncopole of Toulouse

4. an innovating architecture to inspirate multidisciplinary research an innovating architecture to inspirate multidisciplinary research 8700 m 2 of total floor space 5200 m 2 research teams (incl. 3549 m 2 for 21 modules of 184 m 2 ) 800 m 2 administration 2700 m 2 facilities (incl. 2100 m 2 animal facility).

5. a highly attractive scientifico-medical environment a highly attractive scientifico-medical environment Purpan Hospital Team 07 P. Brousset Team 08 S. Manenti/C. Récher Team 09 J.J. Fournié Protéomics (2/2) Biological ressources collection Administration Claudius Regaud Institute Team 03 G. Favre Team 11 E. Moyal/C. Toulas Team 12 M. Poirot/S. Silvente-Poirot Rangueil Hospital Team 04 T. Levade Team 05 H. Prats Team 06 S. Pyronnet/C. Bousquet Team 10 L. Buscail/P. Cordelier Protéomics (1/2) Gene vectors IPBS/CNRS Team 02 J.S. Hoffmann/C. Cazaux LBCMCP Team 01 A. Besson

6. Who are we ?

7. 18 research teams, 250 persons, 80 PhD students & graduates 18 research teams, 250 persons, 80 PhD students & graduates 10 core technological platforms 13,000 cages animal facility 10 core technological platforms 13,000 cages animal facility 18 research teams, 250 persons, 80 PhD students & graduates 18 research teams, 250 persons, 80 PhD students & graduates 10 core technological platforms 13,000 cages animal facility 10 core technological platforms 13,000 cages animal facility

8. Our Core technological platforms Biological Resources Collection (CRCT, CUC) Cell Imaging (CRCT, IFR150) Bioinformatics (CUC, CRCT) Gene vectors (CRCT) Omics (genomics, transcriptomics, proteomics, MS) (CRCT,CUC, IFR150) Flow cytometry & cell sorting (CRCT) Experimental Histopathology (CREFRE, CUC, IFR150) Mab production & protein ingeneering (CRCT) (transgenesis, cryoconservation, genotyping, small animal imaging, …) Mouse Facility CREFRE (UMS006) Analytical Pharmacology (CUC)

9. 2012: More than 200 people dedicated to cancer research Staff: positionsStaff: functions

10. Leading institutions, leading research PositionsFunctions  49%  26%  14%  6%  5%

11. Our Missions, Our results

12. Our missions I. Promote an outstanding fundamental research on cancer II. Accelerate discovery of new drugs, technologies and treatments III. Promote scientific, medical & clinical education of students & staff IV. Accelerate access to new clinical trials at IUC V. Promote economical development (pharma, biotech & other companies )

13. Our results: 5-year indicators of CRCT Our results: 5-year indicators of CRCT 22 million € contracts ~260 graduates ~1000 publications 40 patents 3 start-up companies

14. + new projects Dept 2- Tumor Biology  metabolism  angiogenesis & lymphangiogenesis  translational control of tumor response to stress Dept 1- Molecular biology of cancer cells  CDKi as tumor suppressors & oncogenes  genetic instability of tumor cells  rhoGTPases regulating cancer cell signaling Dept 3- Hematology & Immunology  oncogenesis of T cell lymphoma & leukemia  signaling of Acute Myeloid Leukemia  immunotherapy of B lymphomas Dept 4- Experimental Therapeutics  biomarkers & biotherapies,  therapeutic innovation  tumor radioresistance Departements & thèmes de recherche

15. Our project Our project Grandes Questions en Oncologie

16. Mécanismes Oncogéniques

17. Microenvironnement, Métabolisme, Evolution Tumorale Cancer Cell Metabolism Cancer Cell Metabolism Clonal & Microenvironmental Coevolutions Tumoralstructure Tumoralstructure Tumoralstructure Tumoralstructure

18. Evolution Clinique & Biomarqueurs Prédictifs

19. Innovations Therapeutiques New Chemical Entities (Tki, …) mAbs Natural products Gene therapy Recomb proteins Biological Drugs Synth peptides Oligonucleotides

20. Innovations Technologiques

21. Understand better to defeat cancer

22. … and let’s score the goal together !