1. Occlusion Pressure P0.1

2. Special Procedure Negative airway pressure generated during the first 100 ms of an occluded inspiration P0.1 values reflect neuromuscular activation of the patient during spontaneous breathing An indicator of whether a patient is ready to be weaned Non-aggressive measure during non- forced inspiration

3. How Is It Measured? P0.1 begins where the inspiratory valve remains closed during the first 100 ms of the next inspiratory cycle. The airway pressure during the occlusion is measured by the ventilator´s pressure transducer in the expiratory limb just before the exhalation valve. After measurement, the patient receives the set ventilatory support.

4. What conditions are optimal for this measurement? Mandatory VentilationSpontaneous Breathing When a patient is under mandatory ventilation, the patient often becomes dependent on the ventilator and therefore it is difficult to begin weaning. P0.1 measurement is not recommended during mandatory ventilation because mandatory ventilation does not exercise patient musculatory drive Measurement of occlusion pressure when a patient spontaneously breathes helps the doctor accurately determine patient progress. This measurement helps to distinguish between a healthy and overexerted respiratory drive of a patient. Modes like ASB, BIPAP* and SIMV AutoFlow TM which enhance and support patient efforts are best for this measurement BIPAP* Trademark used under licence. AutoFlow™ Trademark of Drägerwerk AG.

5. Advantages * -0,7 mbar * patient does not improve * remains in hospital * -6,0 mbar * patient hyperventilates * remains in hospital Guided Diagnosis for Physician Controlled Ventilation Spontaneous Ability * -3,0 mbar * patient improves * leaves hospital (could climb a mountain) patient is weak

6. Literature "A new method for P0.1 measurement using standard respiratory equipment”; Kuhlen, Hausmann, et al Clinical consequences of the Implementation of a weaning protocol* Weaning Parameters to Detect Extubation Outcome* Ventilatory Drive and Breathing Pattern for Predicting Outcome of a Weaning Trial* f/Vt Ratio and P0.1 as Predictors of extubation outcome* * Source: Intensive Care Medicine Vol 22 #10, Supp.3