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Corneal Dystrophies ? ? What are the four categories of corneal dystrophies? ? ?

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Presentation on theme: "Corneal Dystrophies ? ? What are the four categories of corneal dystrophies? ? ?"— Presentation transcript:

1 Corneal Dystrophies ? ? What are the four categories of corneal dystrophies? ? ?

2 Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies What are the four categories of corneal dystrophies? Stromal Dystrophies Endothelial Dystrophies

3 Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) ? 2) ? 3) ? 4) ? 5) ? 6) ? What are the six epithelial-stromal TGFBI corneal dystrophies? Stromal Dystrophies Endothelial Dystrophies

4 Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 What are the six epithelial-stromal TGFBI corneal dystrophies? Stromal Dystrophies Endothelial Dystrophies

5 Corneal Dystrophies What are the six non-TGFBI stromal dystrophies?
Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 What are the six non-TGFBI stromal dystrophies? Stromal Dystrophies 1) ? 2) ? 3) ? 4) ? 5) ? 6) ? Endothelial Dystrophies

6 Corneal Dystrophies What are the six non-TGFBI stromal dystrophies?
Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 What are the six non-TGFBI stromal dystrophies? Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies

7 Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Which stromal dystrophies does the BCSC Cornea book consider the ‘classic 3’? Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies

8 Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Which stromal dystrophies does the BCSC Cornea book consider the ‘classic 3’? Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies

9 What is the well-known mnemonic regarding the classic 3?
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 What is the well-known mnemonic regarding the classic 3? Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies

10 Marilyn Monroe Always Gets Her Man in LA County
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 What is the well-known mnemonic regarding the classic 3? Marilyn Monroe Always Gets Her Man in LA County Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Endothelial Dystrophies

11 Marilyn Monroe Always Gets Her Man in LA County
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 What is the well-known mnemonic regarding the classic 3? Marilyn Monroe Always Gets Her Man in LA County Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy What does the mnemonic help us to remember? Endothelial Dystrophies

12 Marilyn Monroe Always Gets Her Man in LA County
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 What is the well-known mnemonic regarding the classic 3? Marilyn Monroe Always Gets Her Man in LA County Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy What does the mnemonic help us to remember? The name, abnormal material, and stain for each of the classic 3 Endothelial Dystrophies

13 Marilyn Monroe Always Gets Her Man in LA County
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Use the mnemonic to identify the names/materials/stains: Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Marilyn Monroe Always Gets granular dystrophy Her hyaline Man Masson trichrome in L lattice dystrophy A amyloid County Congo Red (Start here, and we’ll work our way down the list) What is the well-known mnemonic regarding the classic 3? Marilyn Monroe Always Gets Her Man in LA County Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy What does the mnemonic help us to remember? The name, abnormal material, and stain for each of the classic 3 Endothelial Dystrophies

14 Marilyn Monroe Always Gets Her Man in LA County
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Use the mnemonic to identify the names/materials/stains: Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Marilyn macular dystrophy Monroe mucopolysaccharide Always Alcian blue Gets granular dystrophy Her hyaline Man Masson trichrome in L lattice dystrophy A amyloid County Congo Red What is the well-known mnemonic regarding the classic 3? Marilyn Monroe Always Gets Her Man in LA County Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy What does the mnemonic help us to remember? The name, abnormal material, and stain for each of the classic 3 Endothelial Dystrophies

15 Marilyn Monroe Always Gets Her Man in LA County
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Use the mnemonic to identify the names/materials/stains: Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Marilyn macular dystrophy Monroe mucopolysaccharide Always Alcian blue Gets granular dystrophy Her hyaline Man Masson trichrome in L lattice dystrophy A amyloid County Congo Red What is the well-known mnemonic regarding the classic 3? Marilyn Monroe Always Gets Her Man in LA County Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy What does the mnemonic help us to remember? The name, abnormal material, and stain for each of the classic 3 Endothelial Dystrophies

16 Marilyn Monroe Always Gets Her Man in LA County
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Use the mnemonic to identify the names/materials/stains: Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Marilyn macular dystrophy Monroe mucopolysaccharide Always Alcian blue Gets granular dystrophy Her hyaline Man Masson trichrome in L lattice dystrophy A amyloid County Congo Red What is the well-known mnemonic regarding the classic 3? Marilyn Monroe Always Gets Her Man in LA County Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy What does the mnemonic help us to remember? The name, abnormal material, and stain for each of the classic 3 Endothelial Dystrophies

17 Marilyn Monroe Always Gets Her Man in LA County
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Use the mnemonic to identify the names/materials/stains: Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Marilyn macular dystrophy Monroe mucopolysaccharide Always Alcian blue Gets granular dystrophy Her hyaline Man Masson trichrome in L lattice dystrophy A amyloid County Congo Red What is the well-known mnemonic regarding the classic 3? Marilyn Monroe Always Gets Her Man in LA County Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy What does the mnemonic help us to remember? The name, abnormal material, and stain for each of the classic 3 Endothelial Dystrophies

18 Marilyn Monroe Always Gets Her Man in LA County
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Use the mnemonic to identify the names/materials/stains: Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Marilyn macular dystrophy Monroe mucopolysaccharide Always Alcian blue Gets granular dystrophy Her hyaline Man Masson trichrome in L lattice dystrophy A amyloid County Congo Red What is the well-known mnemonic regarding the classic 3? Marilyn Monroe Always Gets Her Man in LA County Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy What does the mnemonic help us to remember? The name, abnormal material, and stain for each of the classic 3 Endothelial Dystrophies

19 Big 3 stromal dystrophies:
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Big 3 stromal dystrophies: Fill in the table Common? Recur in PK Age of Onset Most ? Earliest Lattice Youngest Macular Granular Least Latest Oldest Endothelial Dystrophies

20 Big 3 stromal dystrophies:
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Big 3 stromal dystrophies: Fill in the table Common? Recur in PK Age of Onset Most Lattice Earliest Youngest Macular Granular Least Latest Oldest Endothelial Dystrophies

21 Big 3 stromal dystrophies:
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Big 3 stromal dystrophies: Fill in the table Common? Recur in PK Age of Onset Most Lattice Earliest ? Youngest Macular Granular Least Latest Oldest Endothelial Dystrophies

22 Big 3 stromal dystrophies:
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Big 3 stromal dystrophies: Fill in the table Common? Recur in PK Age of Onset Most Lattice Earliest Youngest Macular Granular Least Latest Oldest Endothelial Dystrophies

23 Big 3 stromal dystrophies:
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Big 3 stromal dystrophies: Fill in the table Common? Recur in PK Age of Onset Most Lattice Earliest Youngest ? Granular Macular Least Latest Oldest Endothelial Dystrophies

24 Big 3 stromal dystrophies:
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Big 3 stromal dystrophies: Fill in the table Common? Recur in PK Age of Onset Most Lattice Earliest Youngest Macular Granular Least Latest Oldest Endothelial Dystrophies

25 Big 3 stromal dystrophies:
Corneal Dystrophies Epithelial and Subepithelial Dystrophies Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Same order as other two, just shifted down by one Note: Same order Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Big 3 stromal dystrophies: Fill in the table Common? Recur in PK Age of Onset Most Lattice Earliest Youngest Macular Granular Least Latest Oldest Endothelial Dystrophies

26 Corneal Dystrophies Epithelial and Subepithelial Dystrophies
Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Give 6 reasons that macular is the ‘black sheep’ of the big 3 stromal dystrophies: 1) It is AR (others are AD) 2) 3) The cornea is hazy between lesions (others have clear spaces between lesions) 4) It’s gene locus is not TGFBI (others are) 5) The cornea tends to thin in macular (others do not) 6) It involves the deep stroma, and even the endothelium (others are anterior) Endothelial Dystrophies 1) Fuchs endothelial corneal dystrophy

27 Corneal Dystrophies Epithelial and Subepithelial Dystrophies
Epithelial-Stromal TGFBI Dystrophies 1) Reis-Bücklers corneal dystrophy 2) Thiel-Behnke corneal dystrophy 3) Lattice, type 1 4) Lattice, variant types (III, IIIA, I/IIIA, IV) 5) Granular type 1 6) Granular type 2 Stromal Dystrophies 1) Macular corneal dystrophy 2) Schnyder corneal dystrophy 3) Congenital stromal corneal dystrophy 4) Fleck corneal dystrophy 5) Posterior amorphous corneal dystrophy 6) Pre-Descemet corneal dystrophy Give 6 reasons that macular is the ‘black sheep’ of the big 3 stromal dystrophies: 1) It is AR (others are AD) 2) It is limbus-to-limbus (others are clear peripherally) 3) The cornea is hazy between lesions (others have clear spaces between lesions) 4) It’s gene locus is not TGFBI (others are) 5) The cornea tends to thin in macular (others do not) 6) It involves the deep stroma, and even the endothelium (others are anterior) Endothelial Dystrophies 1)

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