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IL-1 receptor–associated kinase 3 gene (IRAK3) variants associate with asthma in a replication study in the Spanish population  María Pino-Yanes, MSc,

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Presentation on theme: "IL-1 receptor–associated kinase 3 gene (IRAK3) variants associate with asthma in a replication study in the Spanish population  María Pino-Yanes, MSc,"— Presentation transcript:

1 IL-1 receptor–associated kinase 3 gene (IRAK3) variants associate with asthma in a replication study in the Spanish population  María Pino-Yanes, MSc, Inmaculada Sánchez-Machín, MD, José Cumplido, MD, Javier Figueroa, MD, María José Torres-Galván, PhD, Ruperto González, MD, Almudena Corrales, CLT, Orlando Acosta-Fernández, MD, José Carlos García-Robaina, MD, Teresa Carrillo, MD, Anselmo Sánchez-Palacios, MD, Jesús Villar, MD, PhD, Mariano Hernández, PhD, Carlos Flores, PhD  Journal of Allergy and Clinical Immunology  Volume 129, Issue 2, Pages e10 (February 2012) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 ORs and their 95% CIs for the SNPs rs and rs in the sequential addition of atopic asthma cases according to age at diagnosis. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Association P values (in log scale) of IRAK3 gene SNPs with atopic asthma diagnosed at age 22 years or less and in a meta-analysis across Europeans. An LD plot of r2 values based on resequencing data is shown for the 58 SNPs of IRAK3, as well as their relative position in the gene. Each diamond of the LD plot represents the pairwise r2 correlation between SNPs. Journal of Allergy and Clinical Immunology  , e10DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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