1. DQs have superior anticancer efficacy among dimeric antimalarials.
DQs have superior anticancer efficacy among dimeric antimalarials. A, Chemical structures of dimeric antimalarials. Ar, aromatic ring. B, Cells were treated with compounds shown (2 weeks, 3 μmol/L) in colony formation assays. C, Calculated log IC50 values from 72-hour MTT assays in A375P (melanoma) cells treated with compounds shown. D, Calculated log IC50 values of indicated compounds (72 hours, 1 nmol/L–30 μmol/L) from MTT assays in A375P cells. E, PANC1 cells were treated as indicated (24 hours, 3 μmol/L), stained with Annexin V, and analyzed using flow cytometry. B–D, For all graphs, mean ± SD for N = 3 independent experiments are presented; *, P < 0.05.
Vito W. Rebecca et al. Cancer Discov 2017;7:
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