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Cabozantinib causes significant tumor cell elimination in vivo, but modest apoptosis induction in vitro. Cabozantinib causes significant tumor cell elimination.

Published byLynn Short Modified over 5 years ago

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Presentation on theme: "Cabozantinib causes significant tumor cell elimination in vivo, but modest apoptosis induction in vitro. Cabozantinib causes significant tumor cell elimination."— Presentation transcript:

1 Cabozantinib causes significant tumor cell elimination in vivo, but modest apoptosis induction in vitro. Cabozantinib causes significant tumor cell elimination in vivo, but modest apoptosis induction in vitro. A, Cabozantinib acutely increased caspase-3 staining within 24 to 48 hours of treatment in established murine PTEN/p53-deficient prostate tumors. Mice were treated with cabozantinib for the indicated times, and prostate tumor tissues were stained with caspase-3 antibody by IHC. Images show representative sections from n = 3 mice per time point. B, PTEN/p53-deficient prostate tumor–derived cell lines treated with cabozantinib showed only modest cell death. SC1, AC1, and AC3 cells were treated with 30 μmol/L cabozantinib for the indicated times, followed by apoptosis analysis with Annexin V staining (n = 3 experiments). *, P < 0.05; **, P < 0.01; ***, P < Akash Patnaik et al. Cancer Discov 2017;7: ©2017 by American Association for Cancer Research

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