Presentation is loading. Please wait.

Presentation is loading. Please wait.

Response of Calu-6 tumors to anti-VEGF therapy.

Published byTeguh Hadiman Modified over 4 years ago

Similar presentations

Presentation on theme: "Response of Calu-6 tumors to anti-VEGF therapy."— Presentation transcript:

1 Response of Calu-6 tumors to anti-VEGF therapy.
Response of Calu-6 tumors to anti-VEGF therapy. A, growth curves of control untreated Calu-6 lung carcinoma–derived xenografted tumors, tumors treated with mAb A4.6.1, or tumors treated with mFlt-IgG. Tumor volume (mm3) over time in days. B and C, sections of the Calu-6 or A673 tumors were stained with antibodies to the endothelial cell marker PVLAP (triangles) and αSMA (arrows). *, tumor cells. Images were taken using differential interference contrast microscopy to visualize the tumor (asterisk) and stromal (arrows) constituents. B, Calu-6 tumors exhibit significant infiltration by stromal cells (arrows) and substantial acellular matrix. Anti-PLVAP staining was used to highlight the vasculature (triangles). C, A673 tumors almost completely comprised primitive skeletal muscle cells (asterisk) with minimal stromal infiltration. Max L. Tejada et al. Clin Cancer Res 2006;12: ©2006 by American Association for Cancer Research

Download ppt "Response of Calu-6 tumors to anti-VEGF therapy."

Similar presentations

AZD9291 inhibits EGFR phosphorylation and downstream signaling in murine models of EGFRT790M-resistant lung cancer. AZD9291 inhibits EGFR phosphorylation.

AZD9291 inhibits EGFR phosphorylation and downstream signaling in murine models of EGFRT790M-resistant lung cancer. AZD9291 inhibits EGFR phosphorylation.
CDK2 is highly expressed in colon cancer cells and curcumin selectively suppresses HCT116 cell proliferation. CDK2 is highly expressed in colon cancer.

CDK2 is highly expressed in colon cancer cells and curcumin selectively suppresses HCT116 cell proliferation. CDK2 is highly expressed in colon cancer.
 (A) Vascular endothelial growth factor D (VEGF-D) staining in luminal ductal cells with occasional staining in myoepithelial cells of normal breast.  (A)

 (A) Vascular endothelial growth factor D (VEGF-D) staining in luminal ductal cells with occasional staining in myoepithelial cells of normal breast.  (A)
Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma.

Sunitinib plus rMVA–CEA–TRICOM vaccine decreased tumor burden and increased intratumoral infiltration of T lymphocytes in the MC38-CEA colon carcinoma.
Sun-Wei Guo, Ding Ding, Xishi Liu  Reproductive BioMedicine Online 

Sun-Wei Guo, Ding Ding, Xishi Liu  Reproductive BioMedicine Online 
XL184 effects on RIP-Tag2 tumor invasion and epithelial/mesenchymal markers. XL184 effects on RIP-Tag2 tumor invasion and epithelial/mesenchymal markers.

XL184 effects on RIP-Tag2 tumor invasion and epithelial/mesenchymal markers. XL184 effects on RIP-Tag2 tumor invasion and epithelial/mesenchymal markers.
Bioluminescence imaging facilitates detection of tumor growth and metastasis in mouse orthotopic xenograft model. Bioluminescence imaging facilitates detection.

Bioluminescence imaging facilitates detection of tumor growth and metastasis in mouse orthotopic xenograft model. Bioluminescence imaging facilitates detection.
Anti-CD20 CAR exPBNK significantly inhibit growth of Raji cells in xenografted mice. Anti-CD20 CAR exPBNK significantly inhibit growth of Raji cells in.

Anti-CD20 CAR exPBNK significantly inhibit growth of Raji cells in xenografted mice. Anti-CD20 CAR exPBNK significantly inhibit growth of Raji cells in.
Morphology of cells used throughout the experiments.

Morphology of cells used throughout the experiments.
CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.

CD8+ T cells were immunomodulated and required for the efficacy of anti–4-1BB/anti–PD-1 combination treatment. CD8+ T cells were immunomodulated and required.
The contributions of anti-Ad antibody and T-cell responses to viral clearance in tumor and antitumor efficacy of Ad5 therapy. The contributions of anti-Ad.

The contributions of anti-Ad antibody and T-cell responses to viral clearance in tumor and antitumor efficacy of Ad5 therapy. The contributions of anti-Ad.
TFAP2A knockdown inhibits tumor growth in vivo.

TFAP2A knockdown inhibits tumor growth in vivo.
In vivo assessment of synergistic activity of MV-CEA and RT in a U87 s

In vivo assessment of synergistic activity of MV-CEA and RT in a U87 s
coTCRcys-transduced T cells control tumor growth in vivo.

coTCRcys-transduced T cells control tumor growth in vivo.
Anti-Flk-1 treatment inhibits growth of s. c. 4T1 and B16 tumors. s. c

Anti-Flk-1 treatment inhibits growth of s. c. 4T1 and B16 tumors. s. c
In vivo thrombosis of tumor vasculature.

In vivo thrombosis of tumor vasculature.
The effect of IAA on tumor growth in an SK-MEL-28 xenograft model.

The effect of IAA on tumor growth in an SK-MEL-28 xenograft model.
Vascular staining in CWR22R xenograft tumors.

Vascular staining in CWR22R xenograft tumors.
VEGF expression in neoplastic and normal prostate tissue.

VEGF expression in neoplastic and normal prostate tissue.
A, one-step viral growth curves: RT treatment increased the virus yield in MV-CEA–treated U87 cells by up to 2 log as compared with MV-CEA infection only.

A, one-step viral growth curves: RT treatment increased the virus yield in MV-CEA–treated U87 cells by up to 2 log as compared with MV-CEA infection only.

Similar presentations

Ads by Google