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A. Lauschke, U.K.M. Teichgräber, U. Frei, K.-U. Eckardt 

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Presentation on theme: "A. Lauschke, U.K.M. Teichgräber, U. Frei, K.-U. Eckardt "— Presentation transcript:

1 ‘Low-dose’ dopamine worsens renal perfusion in patients with acute renal failure 
A. Lauschke, U.K.M. Teichgräber, U. Frei, K.-U. Eckardt  Kidney International  Volume 69, Issue 9, Pages (May 2006) DOI: /sj.ki Copyright © 2006 International Society of Nephrology Terms and Conditions

2 Figure 1 Relationship between the baseline RI and serum creatinine in all patients. NE, norepinephrine. Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions

3 Figure 2 Correlation between the baseline RI and PI in all patients.
Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions

4 Figure 3 Percentage change of RI compared to baseline value after first and second dopamine infusion. A close linear relationship between both values (r=0.74, P<0.0001) indicates high reproducibility of the effect of dopamine. Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions

5 Figure 4 Intraindividual comparison and mean±s.d. of RI values during placebo and dopamine infusion in patients with and without ARF. In patients without ARF dopamine reduced the RI significantly (P<0.01, Wilcoxon test), whereas there was a significant increase in patients with ARF (P<0.01). Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions

6 Figure 5 Effect of dopamine on RI values in patients with and without norepinephrine (NE) infusion. Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions

7 Figure 6 Effect of dopamine on RI values in patients below or above 55 years.* and ° indicate outliers. Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions

8 Figure 7 Schematic presentation of the study design. All patients received ‘low-dose’ dopamine or placebo for two periods of 1 h in alternating sequence and were randomly assigned to two groups receiving either dopamine or placebo first. Kidney International  , DOI: ( /sj.ki ) Copyright © 2006 International Society of Nephrology Terms and Conditions


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