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PD-1 inhibition stimulates the proliferation and cytokine secretion of exhausted/senescent CD8+ T cells in vitro. PD-1 inhibition stimulates the proliferation.

Published byGrzegorz Andrzejewski Modified over 4 years ago

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Presentation on theme: "PD-1 inhibition stimulates the proliferation and cytokine secretion of exhausted/senescent CD8+ T cells in vitro. PD-1 inhibition stimulates the proliferation."— Presentation transcript:

1 PD-1 inhibition stimulates the proliferation and cytokine secretion of exhausted/senescent CD8+ T cells in vitro. PD-1 inhibition stimulates the proliferation and cytokine secretion of exhausted/senescent CD8+ T cells in vitro. A–D, mature moDCs generated from PBMCs from healthy donors were added as stimulators to T cells from patients in a continuous CR (CCR) 1 year after ASCT or T cells from patients who initially achieved CR but relapsed beyond 3 months after ASCT, at a 1:30 ratio with nivolumab or IgG4 isotype control in alloMLRs. After 5 days, cells were harvested, and CD8+CD28negPD-1+ T cells were assessed by flow cytometry for (A) proliferation by Ki-67 expression, and secretion of (B) IFNγ, (C) IL2, and (D) TNFα. Representative dot plots from 1 patient are shown, with pooled data (mean ± SD) from 6 patients, 3 in CCR () and 3 relapsed (), in the far right column for each parameter. **, P < 0.01. David J. Chung et al. Cancer Immunol Res 2016;4:61-71 ©2016 by American Association for Cancer Research

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