2. Automatization for cryopreservation
SMARTFREEZER®
Automatization for cryopreservation
Daniele Pericolini, Marketing Manager Angelantoni Life Science

3. BIOLOGICAL SAMPLE STORAGE
Samples are useful as long as they are stored reliably, protected from accidental and intentional physical damage.
Samples are precious!!
Months of hard work
Unique patient sample
A lot of money spent
Many people involved

4. -196°C liquid or vapor phase
TRADITIONAL STORAGE SYSTEMS
ULT freezers, -80°C
Liquid Nitrogen Tank
-196°C liquid or vapor phase

5. LIMTS OF TRADITIONAL STORAGE SYSTEMS
Manual management systems do not provide a fast and secure recovery of the samples.
Where is my sample?
Each user adopts his own criteria
Many different systems coexist: handwriting, notes, excel files, ​​"in house" databases
Samples stored without any order
Lack of traceability of the individual sample

6. LIMTS OF TRADITIONAL STORAGE SYSTEMS
A wrong labeled sample may be impossible to find
Ice formation on the surface of bottles and boxes heavily complicates the search of samples
Access to the samples by the operator is not recorded
Lack of association between inventory data and physical location of samples
The storage conditions (temperature, humidity) are not reliably monitored

7. LIMTS OF TRADITIONAL STORAGE SYSTEMS
Sample retrieval exposes many other samples to dangerous warming events
The exposure time of the samples at high temperatures is not traced
The number of freeze / thaw cycles is not traced
Sample mix-ups and losses

8. LIMTS OF TRADITIONAL STORAGE SYSTEMS
Loss of data identification / location
Deterioration of samples
Lack of traceability of the cycles of freeze / thaw
Human error
Loss of a sample can result in priceless economic and scientific damage

9. SMARTFREEZER®
The only completely automated device to store biological samples at cryogenic temperature in N2 vapors
Fully automated system
No exposure of the sample to unnecessary freezing-thawing cycles
No operator exposure to liquid nitrogen
Automatic tracking of the sample, historical data and inventory
Integration with LIMS (Laboratory Information Management System)

10. SMARTFREEZER®
Automation
Electronic rack
Storage
Cooling system

11. HOW SMARTFREEZER® WORKS
Vials are usually pre-frozen
Then loaded into Smartfreezer drawer
Identified
Loaded

12. HOW SMARTFREEZER® WORKS
Pneumatic gripper
Withdrawal of a single sample (single picking/cherry picking)
Individual identification of the sample by dot code or barcode

13. HOW SMARTFREEZER® WORKS
Service Tools
Camera installation
Digital camera, HD

14. HOW SMARTFREEZER® WORKS
Service Sw:
User friendly touch Screen Interface
Holes calibration
Fine adjustment
Loading/unloading simulation
Vials identification system

15. Smart Freezer Application
HOW SMARTFREEZER® WORKS
Smart Freezer Application
User friendly touch Screen Interface
Full traceability of loading/unloading
Only authorized people have access to the samples
Interface with customer LIMS (Limfinity, Centraxx, etc..)

16. SMARTFREEZER® KEY POINTS
A single sample at a time is retrieved: no exposure of other samples to dangerous warming events
The right sample is available within few seconds
Cross contamination is not possible
Operator is not exposed to ultra low/cryogenic temperatures
Samples are always identified and tracked
No ice on samples
Mix ups and losses are not possible
User access to samples is tracked
Prevention of accidental and intentional physical damage
Built in match of data inventory and physical sample locations
Complete history of storage operations and temperature conditions

17. VISIT US AT OUR BOOTH FOR A DEMO
#3945