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Top Tips in Evidence-Based Care for HFrEF

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Presentation on theme: "Top Tips in Evidence-Based Care for HFrEF"— Presentation transcript:

1 Top Tips in Evidence-Based Care for HFrEF

2

3 Typical Patient With HFrEF

4 Key Therapies in HFrEF: How Do They Work?

5 2016 ESC HF Guidelines: Next...Add an MRA and ARNI

6 Principles for Successful Treatment for HF

7 Starting and Titrating Drug Therapies in HFrEF

8 ESC 2016 Guidelines: Classifications of HF

9 CHARM: Candesartan Reduced CV Death + Time to First HF Hospitalization in HFrEF and HFmrEF Categories

10 Benefit of ARNI in HFrEF: Primary Composite Endpoint -- CV Death and First HF Hospitalization

11 Additional Key Points: PARADIGM-HF

12 PARADIGM-HF: Benefit of ARNI in HFrEF to Reduce Time to First Hospitalization for HF Was Seen Very Early

13 Managing Diabetes in the Presence of HFrEF

14 SGLT2 Inhibitors: Use in Diabetes and HF

15 Ongoing Trials With SGLT2 Inhibitors in Patients With Diabetes and HF

16 Questions to Ponder and Points of Clarification: SGLT2 Inhibitors in HF

17 Altered Patient Scenario: Tachycardia in HFrEF

18 SHIFT Trial: Increased Risk of CV Death and HF Hospitalization With Increased Heart Rate in SR in HF

19 AF and HF

20 Heart Rate as a Predictor of Outcome in HF

21 Anticoagulation and AF in HF

22 Management of HF in the Inpatient Setting

23 PIONEER HF: Safety of ARNI -- Including ACE Inhibitor and ARB-Naive Patients With HFrEF

24 PIONEER HF: Exploratory Clinical Endpoints

25 Clarification of Terms -- What Do We Mean?

26 Conclusions

27 Abbreviations

28 Abbreviations (cont)

29 Abbreviations (cont)


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