1. Schematic diagram illustrating a theoretical model of amygdala modulation of memory and synaptic plasticity in the hippocampus.
Schematic diagram illustrating a theoretical model of amygdala modulation of memory and synaptic plasticity in the hippocampus. Sensory and contextual stimuli activate specific synapses of the hippocampus (orange arrow), leading to the encoding of declarative or declarative-like memories. The activity-dependent immediate early gene Arc is transcribed and delivered to activated synapses, where it is degraded. In an event that is sufficiently emotionally arousing to be rapidly stored as a long-term memory, the coincident amygdala response to stress hormones directly or indirectly (green arrow) influences translation of Arc mRNA to protein in the recently activated synapse. Fluorescent immunohistochemistry image shows nuclei stained with 4′,6′-diamidino-2-phenylindole (blue) and ARC protein in neuronal cell bodies and dendrites (red) in hippocampal tissue.
Ryan T. LaLumiere et al. Pharmacol Rev 2017;69:
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics