1. a) Mucus replete left lower lobe bronchiectasis in a young X-linked agammaglobulinaemia patient (coronal and axial view). b) Pathogenesis of bronchiectasis and chronic obstructive lung disease in primary antibody deficiencies (PAD).
a) Mucus replete left lower lobe bronchiectasis in a young X-linked agammaglobulinaemia patient (coronal and axial view). b) Pathogenesis of bronchiectasis and chronic obstructive lung disease in primary antibody deficiencies (PAD). In patients with antibody deficiency, a vicious circle involving respiratory tract infections, inflammation and tissue damage/remodelling, possibly facilitated by concomitant non-antibody-related immune defects, might lead to bronchiectasis and fixed airway obstruction [41]. Recurrent infections may trigger recurrent asthma and chronic obstructive pulmonary disease exacerbations.
Francesco Cinetto et al. Eur Respir Rev 2018;27:180019
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