1. Referred visceral hyperalgesia in wild-type (+/+) and Nav1
Referred visceral hyperalgesia in wild-type (+/+) and Nav1.8-null (−/−) mice.
Referred visceral hyperalgesia in wild-type (+/+) and Nav1.8-null (−/−) mice. Referred visceral hyperalgesia was measured as responses to mechanical stimulation of the hindpaws with von Frey hairs of five intensities in wild-type and Nav1.8-null mice. Data are shown as mean percentage response frequency ± SEM before (baseline) and 20 min after intracolonic instillation of 0.1% capsaicin (A), 20 min after intracolonic instillation of 1% mustard oil (B), and 4 hr after 300 mg/kg intraperitoneal cyclophosphamide (C). ∗p < 0.05, indicates forces where a significant difference between +/+ and −/− mice was observed. ANOVA revealed a significant difference overall between genotypes 20 min after intracolonic capsaicin (p = 0.03) and mustard oil (p = 0.02) but not after cyclophosphamide.
Jennifer M. A. Laird et al. J. Neurosci. 2002;22:
©2002 by Society for Neuroscience