1. (histological continuity)
Supplementary Figure 1A
Spleen
Pancreatic cut margin
Blue: microscopic neoplastic lesion (MNL)
Green: high-grade (HG) IPMN
Red: invasive carcinoma (INV)
Pancreatic cut margin
Cranial
Pancreatic tail
Ventral
Section F
Section J
Section K
Section U
HG IPMN
INV
INV
Transition
(histological continuity)
HG IPMN
HG IPMN
-INV
Transition
Transition
Transition
INV
HG IPMN-INV
HG IPMN

2. Supplementary Figure 1B
Section E
LG IPMN
Cystic duct
Stomach
Bile duct margin
Pancreatic cut margin
LG IPMN (MPD) A B C E D F
Section H G
LG IPMN (Santorini) H I J K
Duodenum L
Cranial
Ventral A G
Left
INV B H
Pancreatic cut margin
LG IPMN C I
no histological continuity
Duodenum
Accessory papilla D J
INV E K
Section I
Ampulla of Vater F L
MNL
Caudal
Blue: microscopic neoplastic lesion (MNL)
Yellow: low-grade (LG) IPMN
Green: HG PanIN
Red: INV