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Janette K. Burgess, PhD, Brian G. G. Oliver, PhD, Maree H

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Presentation on theme: "Janette K. Burgess, PhD, Brian G. G. Oliver, PhD, Maree H"— Presentation transcript:

1 A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro 
Janette K. Burgess, PhD, Brian G.G. Oliver, PhD, Maree H. Poniris, BSc(Hons), Qi Ge, BSc, Sarah Boustany, MSc, Natalie Cox, BSc(Hons), Lyn M. Moir, PhD, Peter R.A. Johnson, PhD, Judith L. Black, MBBS, PhD  Journal of Allergy and Clinical Immunology  Volume 118, Issue 3, Pages (September 2006) DOI: /j.jaci Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Corticosteroids (A-C) and LABAs (D-F) induction of fibronectin (A and D), versican (B and E), and IL-6 release (C and F). Data are means ± SEMs from n = 6-7 asthmatic and n = 6-7 nonasthmatic. ∗Significantly greater than 0.1% ITS, P < .02. Bud, Budesonide; Flut, fluticasone; Formot, formoterol; Salmet, salmeterol. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Effect of corticosteroids (A-C) and LABAs (D-F) on TGF-β–induced deposition of fibronectin (A and D), versican (B and E), and IL-6 release (C and F). Data are means ± SEMs from n = 6-7 asthmatic and n = 6-7 nonasthmatic. ∗Significantly greater than 0.1% ITS, P < .04; #significantly different from TGF-β, P < .05. Bud, Budesonide; Flut, fluticasone; Formot, formoterol; Salmet, salmeterol. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Effect of roflumilast on TGF-β–induced fibronectin and versican deposition and IL-6 release from ASM cells. Roflumilast effect on TGF-β–induced deposition of fibronectin (A), versican (B), and IL-6 release (C). Data are means ± SEMs from n = 5 asthmatic and n = 3 nonasthmatic. ∗Significantly greater than 0.1% ITS, P < .03; #significantly different from TGF-β + DMSO, P < .04. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

5 Fig 4 Effect of corticosteroids, LABAs, or roflumilast on TGF-β–induced CTGF, collagen, and fibronectin in nonasthmatic bronchial rings. Immunohistochemical detection of CTGF, collagen I, and fibronectin (brown staining) after stimulation with TGF-β in the presence or absence of drugs in nonasthmatic tissue sections. These changes are shown graphically in A, B, and C. Roflumilast effect on TGF-β–induced CTGF (A), collagen I (B), and fibronectin (C) in nonasthmatic bronchial rings. Data are means ± SEMs from n = 5. ∗Significantly greater than 0.1% ITS, P < .01, #significantly different from TGF-β + DMSO, P < .003. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

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