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Volume 11, Issue 1, Pages (January 2004)

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Presentation on theme: "Volume 11, Issue 1, Pages (January 2004)"— Presentation transcript:

1 Volume 11, Issue 1, Pages 87-97 (January 2004)
Biosynthesis of the Angiogenesis Inhibitor Borrelidin by Streptomyces parvulus Tü4055  Carlos Olano, Barrie Wilkinson, César Sánchez, Steven J Moss, Rose Sheridan, Vidya Math, Alison J Weston, Alfredo F Braña, Christine J Martin, Markiyan Oliynyk, Carmen Méndez, Peter F Leadlay, José A Salas  Chemistry & Biology  Volume 11, Issue 1, Pages (January 2004) DOI: /j.chembiol

2 Figure 1 Structure of Borrelidin
Chemistry & Biology  , 87-97DOI: ( /j.chembiol )

3 Figure 2 Schematic Representation of the Borrelidin Gene Cluster
B, BamHI. ORFs involved in borrelidin biosynthesis are colored in black and those not involved in gray or white, the gray ones corresponding to homologous genes in S. coelicolor showing the same genetic organization. Chemistry & Biology  , 87-97DOI: ( /j.chembiol )

4 Figure 3 Scheme Representing the Repeated DNA Sequences within the Borrelidin PKS Genes Chemistry & Biology  , 87-97DOI: ( /j.chembiol )

5 Figure 4 Module Organization in the Borrelidin PKS and Proposed Model for Borrelidin Biosynthesis ACP, acyl carrier protein; AT, acyltransferase; ATa, malonyl-specific acyltransferase; ATp, methylmalonyl-specific acyltransferase; ER, enoyl reductase; KR, β-keto reductase; DH, dehydratase; KS, β-ketoacyl-acylcarrier protein synthase; TE, thioesterase. Chemistry & Biology  , 87-97DOI: ( /j.chembiol )

6 Figure 5 Putative Biosynthetic Pathway for Trans-1,2-CPDA from 4HPA
Chemistry & Biology  , 87-97DOI: ( /j.chembiol )


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