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Glomerular disease related to anti-VEGF therapy

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Presentation on theme: "Glomerular disease related to anti-VEGF therapy"— Presentation transcript:

1 Glomerular disease related to anti-VEGF therapy
M. Barry Stokes, Maria C. Erazo, Vivette D. D'Agati  Kidney International  Volume 74, Issue 11, Pages (December 2008) DOI: /ki Copyright © 2008 International Society of Nephrology Terms and Conditions

2 Figure 1 Glomerulus showing narrow duplication of glomerular basement membranes with rare cellular interposition, consistent with subacute/chronic thrombotic microangiopathy (periodic acid Schiff reaction; original magnification × 400). Kidney International  , DOI: ( /ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

3 Figure 2 Glomerulus shows capillary collapse and hyperplasia of overlying epithelial cells containing prominent cytoplasmic protein droplets (periodic acid Schiff reaction; original magnification × 600). Kidney International  , DOI: ( /ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

4 Figure 3 Immunofluorescence microscopy shows global finely granular peripheral capillary wall staining for IgA (original magnification × 400). Kidney International  , DOI: ( /ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions

5 Figure 4 Electron microscopy shows marked subendothelial accumulation of ill-defined electron lucent material and no immune-type electron dense deposits (original magnification × 30,000). Kidney International  , DOI: ( /ki ) Copyright © 2008 International Society of Nephrology Terms and Conditions


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