1. Fertility Center
HOW MANY DOES IT TAKE? ACHIEVEMENT OF EUPLOID BLASTOCYST (BL) AS THE PRIMARY PREDICTOR OF LIVE BIRTH (LB) IN OOCYTE CRYOPRESERVATION (OC)
Shannon DeVore MD, Sarah Druckenmiller MD, James Grifo MD PhD, Mary Elizabeth Fino MD, Kara N. Goldman MD, Nicole Noyes MD

2. OBJECTIVE
Current data suggests that live birth following transfer of a euploid embryo is independent of age or type of ART treatment
At our center, we have performed >3,000 independent cycles of both oocyte cryopreservation and trophectoderm biopsy with preimplantation genetic screening (TEBX-PGS)
Recently, we have started using the two technologies together
Aim: to estimate the number of cryopreserved MII oocytes required to achieve live birth at different ages
Design: Retrospective cohort study
Fertility Center

3. No. MII Needed to Achieve 1 Euploid Embryo
MATERIALS & METHODS
Data from 152 patients (202 retrievals, 167 thaws) who underwent autologous oocyte thaws with intended TEBX-PGS
No. MII Needed
to Achieve
1 Euploid Embryo
No. Thawed MII
No. Euploid Embryos =
No. MII Needed
to Achieve
1 Live Birth
No. MII Needed to Achieve 1 Euploid Embryo
Live Birth Rate
per Euploid Embryo =
58%
Fertility Center

4. 8 11 13 14 20 22 RESULTS Age (y) 25 – 34 (n = 23) 35 – 37 (n = 61)
38 – 40
(n = 118)
No. MII Needed to Achieve 1 Euploid Embryo 8
(385/48) 11
(698/60) 13
(1088/84)
No. MII Needed to Achieve 1 Live Birth 14
(8/0.58) 20
(12/0.58) 22
(13/0.58)
Fertility Center

5. CONCLUSIONS
Euploid embryos have a relatively uniform efficiency  achievement of a euploid embryo after oocyte cryopreservation, thaw and fertilization can help estimate the theoretical number of cryopreserved MII oocytes required to achieve 1 live birth
One criticism of oocyte cryopreservation is that it provides women with a false sense of security
Many studies that aim to predict oocyte cryopreservation birth probabilities are limited by lack of autologous oocyte thaw data, and use a subset of the IVF population as a surrogate for oocyte cryopreservation patients, limiting their applicability
Our findings can serve as a counseling tool by providing women with realistic outcomes of oocyte cryopreservation at out center
Fertility Center