1. Volume 126, Issue 3, Pages 683-692 (March 2004)
The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-d-aspartate receptor 
Robert Paul Willert, Clifford J. Woolf, Anthony Robert Hobson, Claire Delaney, David G. Thompson, Qasim Aziz 
Gastroenterology 
Volume 126, Issue 3, Pages (March 2004)
DOI: /j.gastro

2. Figure 1
(A and B) The effect of IV ketamine (■) on (A) esophageal and (B) foot pain thresholds compared with IV saline (♦) (AUC, P = 0.36 esophagus and P = 0.34 foot). Data shown are group mean ± SEM in 6 subjects demonstrating no change in pain threshold following cessation of ketamine vs. saline infusions. Shaded areas show 95% CI saline.
Gastroenterology  , DOI: ( /j.gastro )

3. Figure 2
(A and B) The effect of IV ketamine on proximal (A) esophageal and (B) foot pain thresholds when given prior to and during a distal esophageal intraluminal acid infusion. IV ketamine (■) prevented the reduction in pain threshold in the proximal esophagus to distal esophageal intraluminal acid (P < 0.01 ketamine vs. saline) compared with IV saline (♦) but had no effect on foot pain thresholds. Data shown are group mean ± SEM (n = 14). Shaded areas show 95% CI saline (no acid).
Gastroenterology  , DOI: ( /j.gastro )

4. Figure 3
The effect of IV ketamine on attention scores in protocol 2. Data demonstrate an effect of IV ketamine on attention during the infusion (∗P < 0.01 ketamine [light gray bars] vs. saline [dark gray bars]), which had ceased within 30 minutes of stopping the infusion.
Gastroenterology  , DOI: ( /j.gastro )

5. Figure 4
(A and B) The effect of IV ketamine on proximal (A) esophageal and (B) foot pain thresholds when given following a distal esophageal intraluminal acid infusion. IV ketamine reversed the reduction in pain threshold in the proximal esophagus to distal esophageal intraluminal acid (P < 0.01 ketamine [♦] vs. saline [■]). Data shown are group mean ± SEM. Ketamine had no effect on pain threshold in the foot compared with saline (n = 12). Shaded areas show 95% CI saline (no acid).
Gastroenterology  , DOI: ( /j.gastro )

6. Figure 5
The effect of IV ketamine on attention scores in protocol 3. Data demonstrate an effect of ketamine on attention during the infusion (∗P < 0.01 ketamine [light gray bars] vs. saline [dark gray bars]), which had ceased within 30 minutes of stopping the infusion.
Gastroenterology  , DOI: ( /j.gastro )

7. Figure 6
The number of subjects reporting symptoms during the infusion of IV ketamine and IV saline in all protocols.
Gastroenterology  , DOI: ( /j.gastro )