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The Journal of Allergy and Clinical Immunology: In Practice

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1 The Journal of Allergy and Clinical Immunology: In Practice
Tiotropium reduces airflow obstruction in asthma patients, independent of body mass index  Sandhya Khurana, MD, Pierluigi Paggiaro, MD, Roland Buhl, MD, Jonathan A. Bernstein, MD, FACP, CCI, Jennifer Haddon, MSc, Anna Unseld, Dipl. Stat, Michael Engel, MD, Thomas B. Casale, MD, Anne E. Dixon, MD  The Journal of Allergy and Clinical Immunology: In Practice  DOI: /j.jaip Copyright © 2019 The Authors Terms and Conditions

2 Figure 1 Study design for (A) PrimoTinA-asthma (B) MezzoTinA-asthma, and (C) GraziaTinA-asthma. HFA-MDI, Hydrofluoroalkane metered-dose inhaler; ICS, inhaled corticosteroid; LABA, long-acting beta-agonist. The trials included adult patients aged 18 to 75 years. Patients in the 2 PrimoTinA-asthma trials had symptomatic severe asthma, patients in the 2 MezzoTinA-asthma trials had symptomatic moderate asthma, and patients in the GraziaTinA-asthma trial had symptomatic mild asthma. The Journal of Allergy and Clinical Immunology: In Practice DOI: ( /j.jaip ) Copyright © 2019 The Authors Terms and Conditions

3 Figure E1 FEV1(0-3h) peak and FEV1 trough adjusted placebo-corrected mean change from baseline. A, Tiotropium 5 μg FEV1(0-3h) peak levels. B, Tiotropium 5 μg FEV1 trough levels. C, Tiotropium 2.5 μg FEV1(0-3h) peak levels. D, Tiotropium 2.5 μg FEV1 trough levels. BMI, Body mass index; FEV1, forced expiratory volume in 1 second; FEV1(0-3h), forced expiratory volume in 1 second 3 hours postdose. The Journal of Allergy and Clinical Immunology: In Practice DOI: ( /j.jaip ) Copyright © 2019 The Authors Terms and Conditions

4 Figure E2 FEV1(0-3h) peak adjusted mean change from baseline vs placebo across the continuous range of BMI values for (A) tiotropium 5 μg vs placebo and (B) tiotropium 2.5 μg vs placebo. BMI, Body mass index; CI, confidence interval; FEV1, forced expiratory volume in 1 second; FEV1(0-3h), forced expiratory volume in 1 second 3 hours postdose; Tio, tiotropium. The Journal of Allergy and Clinical Immunology: In Practice DOI: ( /j.jaip ) Copyright © 2019 The Authors Terms and Conditions

5 Figure E3 FEV1 trough adjusted mean change from baseline vs placebo across the continuous range of BMI values for (A) tiotropium 5 μg vs placebo and (B) tiotropium 2.5 μg vs placebo. BMI, Body mass index; CI, confidence interval; FEV1, forced expiratory volume in 1 second; Tio, tiotropium. The Journal of Allergy and Clinical Immunology: In Practice DOI: ( /j.jaip ) Copyright © 2019 The Authors Terms and Conditions

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