1. Biomarkers detected in the serum of rat recipients of intraomental biologic scaffold and intrahepatic syngeneic islets.
Biomarkers detected in the serum of rat recipients of intraomental biologic scaffold and intrahepatic syngeneic islets. Aliquots of 1,300 IEQ from the same syngeneic donor rat islet batch were transplanted in parallel either within the intraomental biologic scaffold (omentum [○]) or the intrahepatic site (liver [●]). Blood samples were collected from indwelling JVC for detection of biomarker levels in circulation. Data presented are mean ± SEM (n = 4–7 per time point). A and B: Metabolic markers assessed at 1 h posttransplant. A: Insulin in μg/mL (*P = 0.018). B: C-peptide in μg/mL. Inflammation markers assessed 24 h posttransplant: MCP-1/CCL2 in pg/mL (C), IL-6 in pg/mL (D), leptin in pg/mL (*P = 0.013) (E), haptoglobin in μg/mL (F), and α2-macroglobulin in μg/mL (**P < 0.03) (G).
Dora M. Berman et al. Diabetes 2016;65:
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