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Vitamin B12 (cobalamin) is a cofactor in conversion of methylmalonyl coenzyme A (CoA) to succinyl CoA and of homocysteine to methionine. Vitamin B12 (cobalamin)

Published byAbigayle Lee Modified over 5 years ago

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Presentation on theme: "Vitamin B12 (cobalamin) is a cofactor in conversion of methylmalonyl coenzyme A (CoA) to succinyl CoA and of homocysteine to methionine. Vitamin B12 (cobalamin)"— Presentation transcript:

1 Vitamin B12 (cobalamin) is a cofactor in conversion of methylmalonyl coenzyme A (CoA) to succinyl CoA and of homocysteine to methionine. Vitamin B12 (cobalamin) is a cofactor in conversion of methylmalonyl coenzyme A (CoA) to succinyl CoA and of homocysteine to methionine. Elevated levels of the substrates methylmalonic acid and homocysteine can be used to detect ‘functional’ B12 deficiency despite normal serum B12 concentrations. Alexander G Thompson et al. Pract Neurol 2015;15: ©2015 by BMJ Publishing Group Ltd

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