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Bingbing Liang, Varun Mahans , Liesbet Geris

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Presentation on theme: "Bingbing Liang, Varun Mahans , Liesbet Geris"— Presentation transcript:

1 Bingbing Liang, Varun Mahans , Liesbet Geris
Model assisted design of 3D printed biomaterials for optimized bone regeneration in alveolar bone Bingbing Liang, Varun Mahans , Liesbet Geris

2 The model design optimization progress is shown in the below flow chart.
3D structures In vitro experiment Structure optimization In vivo evaluation Application: alveolar bone regeneration Basic shape modeling 24/07/2019 All rights reserved © 2018

3 Work in progress Upcoming work
3D structures In vitro experiment Structure optimization In vivo evaluation Application: alveolar bone regeneration Basic shape modeling 24/07/2019 All rights reserved © 2018

4 The curvature-based principles to simulate the neotissue growth in the porous scaffold.
Guyot et al. (2015) 24/07/2019 All rights reserved © 2018

5 Sintering Temperature
The effects of multiple influencing factors have been verified through the pilot experiment. Pore shapes Pore size 0.5/0.7/1/2mm Materials HA/HA-TCP Sintering Temperature 1130/1230°C Cell type Human periosteum derived cells 2 mm The related variable: pore shapes, pore size, materials, sintering temperature, cell type Pilot plate: 3D printed, random distribution 24/07/2019 All rights reserved © 2018

6 The first result shows that the neotissue growth at experiment is much lower than computer modeling.
Qualitatively, the curvature-based principle seems to hold for the tested experimental condition. Quantitatively, a recalibration of the advection velocity needs to be performed as the current value is too high in comparison to the results obtained for the CaP scaffold. 24/07/2019 All rights reserved © 2018

7 Conclusion 3D structures In vitro experiment Structure optimization
In vivo evaluation Application: alveolar bone regeneration Basic shape modeling 24/07/2019 All rights reserved © 2018

8 Acknowledgements Names of co-authors
Varun Manhas, France Lambert, Dorien Van Hede, Liesbet Geris This work is part of BIOPTOS, a certified BioWin project financed by the Walloon region (DG06). BL is funded by the National Fund for Scientific Research FNRS (T )

9 References： [1] Guyot Yann. A multiphysics multiscale computational framework for the simulation of perfusion bioreactor processes in bone tissue engineering, 2015 24/07/2019 All rights reserved © 2018

10 Thank you for your attention!
24/07/2019 All rights reserved © 2018

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